Zhang Chao, Liang Bin, Wang Chendan, Wei Zhiwen, Yun Keming
Forensic Medicine of Shanxi Medical University Taiyuan 030001, China.
Department of Cardiology, The Second Hospital of Shanxi Medical University Taiyuan 030001, China.
Int J Clin Exp Med. 2015 Oct 15;8(10):18500-5. eCollection 2015.
An animal model using beagle dog has been established to investigate the postmortem redistribution of lidocaine.
18 dogs were euthanized and injected lidocaine (13 mg/kg) via epidural immediately. An autopsy was performed at 0, 12, 24, 48, 72, 96 hours after drug administration. All animals were stored in supine position at room temperature. For the other groups, lidocaine was given via epidural 6, 12, 24 hours after dogs were euthanized. Followed treatments were as above described. All samples were treated for detection of the concentration of lidocaine.
It was found that lidocaine could diffuse via blood vessel rapidly post administration. And the concentration of lidocaine in the blood from ventriculus sinister increased obviously in a time-dependent manner. Meanwhile, the postmortem tissue distribution of lidocaine was significantly different. However, the process of postmortem redistribution of lidocaine was obviously delayed in dogs which were given drugs after death.
Together results revealed the process of postmortem redistribution of lidocaine via epidural injection, and provided the method to distinguish the lidocaine-induced death and drug administration after death.
建立一种使用比格犬的动物模型，以研究利多卡因的死后再分布。
对18只犬实施安乐死后立即经硬膜外注射利多卡因（13mg/kg）。给药后0、12、24、48、72、96小时进行尸检。所有动物均在室温下仰卧保存。对于其他组，在犬安乐死后6、12、24小时经硬膜外给予利多卡因。后续处理如上所述。所有样本均进行处理以检测利多卡因浓度。
发现给药后利多卡因可迅速通过血管扩散。左心室血液中利多卡因浓度明显呈时间依赖性增加。同时，利多卡因的死后组织分布存在显著差异。然而，死后给药的犬中利多卡因的死后再分布过程明显延迟。
综合结果揭示了经硬膜外注射利多卡因的死后再分布过程，并提供了区分利多卡因诱导死亡和死后给药的方法。
