Liu Lanping, Shi Fang, Li Shanshan, Liu Xiuju, Wei Lili, Zhang Jian, Ju Xiao, Yu Jinming
Department of Oncology, Shandong UniversityJinan, China; Department of Radiation Oncology, Shandong Cancer Hospital and InstituteJinan, China.
Department of Radiology, Shandong Cancer Hospital and Institute Jinan, China.
Int J Clin Exp Med. 2015 Oct 15;8(10):19460-5. eCollection 2015.
The etiology of lung cancer is still incompletely understood. Previous studies have suggested the association between IL-21 polymorphisms and autoimmune diseases, however, little is known about its role in lung cancer susceptibility. Here, we investigated the role of two SNPs of IL-21 gene in a cohort of non-small cell lung cancer (NSCLC) patients. A total of 128 NSCLC patients and 156 healthy controls were genotyped. Multivariate logistic regression was used to analyze the association between IL-21 polymorphisms and NSCLC risk. Our data showed that both rs907715 and rs2221903 were significantly associated with lung cancer susceptibility, and patients carrying rs907715A (P = 0.007, adjusted OR = 0.60, 95% CI = 0.42-0.87) or rs2221903G (P = 0.020, adjusted OR = 0.52, 95% CI = 0.30-0.90) allele had a decreased risk of NSCLC. Further study identified that the association between IL-21 polymorphisms and NSCLC risk was limited to lung adenocarcinoma. Haplotype analysis revealed that the AG (P = 0.006, OR = 0.072 95% CI = 0.011-0.451) and AA (P = 0.022, OR = 0.657, 95% CI = 0.458-0.941) haplotypes of rs907715/rs2221903 were associated with a decreased risk of NSCLC, whereas the GA (P = 0.0001, OR = 1.932, 95% CI = 1.378-2.710) haplotype was associated with an increased risk. In conclusion, our study demonstrates the association between IL-21 polymorphisms (rs907715 and rs2221903) and NSCLC risk in a Chinese Han population, indicating their potential role in lung cancer detection and treatment.
肺癌的病因仍未完全明确。先前的研究表明白细胞介素-21（IL-21）基因多态性与自身免疫性疾病之间存在关联，然而，其在肺癌易感性中的作用却知之甚少。在此，我们研究了IL-21基因的两个单核苷酸多态性（SNP）在一组非小细胞肺癌（NSCLC）患者中的作用。对总共128例NSCLC患者和156例健康对照进行了基因分型。采用多因素逻辑回归分析IL-21基因多态性与NSCLC风险之间的关联。我们的数据表明，rs907715和rs2221903均与肺癌易感性显著相关，携带rs907715A（P = 0.007，校正比值比[OR]=0.60，95%可信区间[CI]=0.42 - 0.87）或rs2221903G（P = 0.020，校正OR = 0.52，95%CI = 0.30 - 0.90）等位基因的患者患NSCLC的风险降低。进一步研究发现，IL-21基因多态性与NSCLC风险之间的关联仅限于肺腺癌。单倍型分析显示，rs907715/rs2221903的AG（P = 0.006，OR = 0.072，95%CI = 0.011 - 0.451）和AA（P = 0.022，OR = 0.657，95%CI = 0.458 - 0.941）单倍型与NSCLC风险降低相关，而GA（P = 0.0001，OR = 1.932，95%CI = 1.378 - 2.710）单倍型与风险增加相关。总之，我们的研究证明了IL-21基因多态性（rs907715和rs2221903）与中国汉族人群NSCLC风险之间的关联，表明它们在肺癌检测和治疗中的潜在作用。
