Yook Jin-Seon, Kim Kyung-Ah, Park Jeong Eun, Lee Seon-Hwa, Cha Youn-Soo
Department of Food Science and Human Nutrition, Brain Korea 21 Plus, Chonbuk National University, Jeonbuk 54896, Korea.
Department of Food and Nutrition, Songwon University, Gwanju 61756, Korea.
Prev Nutr Food Sci. 2015 Dec;20(4):230-7. doi: 10.3746/pnf.2015.20.4.230. Epub 2015 Dec 31.
This study investigated the impact of microalgal oil (MO) on body weight management in C57BL/6J mice. Obesity was induced for 8 weeks and animals were orally supplemented with the following for 8 additional weeks: beef tallow (BT), corn oil, fish oil (FO), microalgal oil (MO), or none, as a high fat diet control group (HD). A normal control group was fed with a normal diet. After completing the experiment, the FO and MO groups showed significant decreases in body weight gain, epididymal fat pad weights, serum triglycerides, and total cholesterol levels compared to the HD and BT groups. A lower mRNA expression level of lipid anabolic gene and higher levels of lipid catabolic genes were observed in both FO and MO groups. Serum insulin and leptin concentrations were lower in the MO group. These results indicated that microalgal oil has an anti-obesity effect that can combat high fat diet-induced obesity in mice.
本研究调查了微藻油（MO）对C57BL/6J小鼠体重管理的影响。诱导肥胖8周后，动物再口服补充以下物质8周：牛脂（BT）、玉米油、鱼油（FO）、微藻油（MO），或不补充作为高脂饮食对照组（HD）。正常对照组给予正常饮食。实验结束后，与HD组和BT组相比，FO组和MO组的体重增加、附睾脂肪垫重量、血清甘油三酯和总胆固醇水平均显著降低。FO组和MO组均观察到脂质合成基因的mRNA表达水平较低，脂质分解基因水平较高。MO组的血清胰岛素和瘦素浓度较低。这些结果表明，微藻油具有抗肥胖作用，可对抗高脂饮食诱导的小鼠肥胖。
