性别特异性的大鼠离体比目鱼肌去负荷神经肌肉适应性变化
Gender-specific neuromuscular adaptations to unloading in isolated rat soleus muscles.
作者信息
Deschenes Michael R, Leathrum Colleen M
机构信息
Department of Kinesiology & Health Sciences, College of William & Mary, Williamsburg, Virginia, 23187-8795, USA.
Program in Neuroscience, College of William & Mary, Williamsburg, Virginia, USA.
出版信息
Muscle Nerve. 2016 Aug;54(2):300-7. doi: 10.1002/mus.25038. Epub 2016 May 20.
INTRODUCTION
The potential of gender to affect unloading-induced neuromuscular adaptations was investigated.
METHODS
Twenty male and 20 female rats were assigned to control (CTL), or unloaded (UL) conditions. After 2 weeks of unloading, soleus muscles were removed, and neuromuscular function was assessed during a train of alternating indirect (neural) and direct (muscle) stimuli.
RESULTS
In rested muscle, strength showed significant (P ≤ 0.05) main effects for gender (male > female) and treatment (CTL > UL). By the end of the testing protocol, when muscles showed fatigue, gender-related and treatment-related differences in strength had disappeared. Neuromuscular transmission efficiency and strength suffered a greater decline during the testing protocol in males than females. Unloaded male muscles displayed greater contractile velocity than female muscles both when rested and fatigued.
CONCLUSIONS
Gender affected unloading-induced neuromuscular adaptations. The greater strength of rested male muscles was due to greater muscle mass and neuromuscular transmission efficiency. Muscle Nerve 54: 300-307, 2016.
引言
研究了性别对卸载诱导的神经肌肉适应性的影响。
方法
将20只雄性大鼠和20只雌性大鼠分为对照组（CTL）或卸载组（UL）。卸载2周后，取出比目鱼肌，并在一系列交替的间接（神经）和直接（肌肉）刺激过程中评估神经肌肉功能。
结果
在静息肌肉中，力量在性别（雄性>雌性）和处理（CTL>UL）方面显示出显著（P≤0.05）的主效应。在测试方案结束时，当肌肉出现疲劳时，力量上与性别和处理相关的差异消失。在测试方案期间，雄性的神经肌肉传递效率和力量下降幅度大于雌性。无论静息还是疲劳状态下，卸载的雄性肌肉比雌性肌肉表现出更高的收缩速度。
结论
性别影响卸载诱导的神经肌肉适应性。静息雄性肌肉更强的力量归因于更大的肌肉质量和神经肌肉传递效率。《肌肉与神经》54: 300 - 307, 2016年。
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