Singh Ankita, Khatri Vinod, Malhotra Shashwat, Prasad Ashok K
Bioorganic Laboratory, Department of Chemistry, University of Delhi, Delhi 110007, India.
Bioorganic Laboratory, Department of Chemistry, University of Delhi, Delhi 110007, India.
Carbohydr Res. 2016 Feb 8;421:25-32. doi: 10.1016/j.carres.2015.12.006. Epub 2015 Dec 23.
A convergent template assisted synthesis of sugar-based chiral macrocycles has been achieved. The host-guest inclusion studies have revealed significant interactions of the synthesized macrocycle with primary over secondary ammonium salt. The chiral macrocyle also discriminates between D- and L-phenylalanine methyl ester hydrochlorides as revealed by (1)H NMR spectral studies on the mixture of the host and the guest molecules.
已实现基于糖的手性大环化合物的收敛模板辅助合成。主客体包合研究表明，合成的大环化合物与伯铵盐而非仲铵盐之间存在显著相互作用。如通过对主体和客体分子混合物的核磁共振氢谱研究所示，手性大环化合物还能区分D-和L-苯丙氨酸甲酯盐酸盐。
