Zhang Wei Chuan, Tang Xue, Lu Xiaoming
Department of Chemistry, Capital Normal University, Beijing 100048, China.
Department of Chemistry, Capital Normal University, Beijing 100048, China; State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fujian, Fuzhou 350002, China.
J Inorg Biochem. 2016 Mar;156:105-12. doi: 10.1016/j.jinorgbio.2016.01.007. Epub 2016 Jan 11.
Three novel copper(II) compounds of formulas {[Cu(Phen)(Ala)]·NO3·H2O}n (1), {[Cu(Phen)(Ala)]·NO3}n (2) and [Cu(Ala)2]n (3) have been synthesized and determined by X-ray diffraction. 1 and 2 are shown in one dimensional long-chain chiral structures, and 3 is a two dimensional checkerboard-type structure. Both 1 and 2 displayed a higher anticancer activity than 3 against various cancer cells, even higher than the similar mononuclear complexes and clinical anticancer drug 5-fluorouracil. The noncancerous cell lines (CCC-HEL-1) have showed that complexes 1-3 have hardly any cytotoxicity. Transmission electron microscopy was studied to show the nano-structure and π function of two complexes. The ligand 1,10-phenanthroline inserted into its enantiomer lead complex 1 stable, and the π-π interaction outside the chain made complex 2 active, which is easy to crack and pile up together. In addition, the energy gaps, UV-vis, luminescent and cyclic voltammetry were experimented to show the stable one dimensional long-chain chiral structure and the π function of two complexes.
已合成了三种化学式分别为{[Cu(Phen)(Ala)]·NO3·H2O}n (1)、{[Cu(Phen)(Ala)]·NO3}n (2)和[Cu(Ala)2]n (3)的新型铜(II)化合物，并通过X射线衍射对其进行了测定。1和2呈现出一维长链手性结构，3是二维棋盘型结构。1和2对各种癌细胞均表现出比3更高的抗癌活性，甚至高于类似的单核配合物和临床抗癌药物5-氟尿嘧啶。非癌细胞系(CCC-HEL-1)表明配合物1 - 3几乎没有任何细胞毒性。通过透射电子显微镜研究了两种配合物的纳米结构和π功能。配体1,10 - 菲咯啉插入其对映体铅配合物1使其稳定，链外的π - π相互作用使配合物2具有活性，其易于裂解并堆积在一起。此外，还进行了能隙、紫外可见、发光和循环伏安实验，以展示两种配合物稳定的一维长链手性结构和π功能。
