Vušak Darko, Ležaić Katarina, Jurec Jurica, Žilić Dijana, Prugovečki Biserka
Department of Chemistry, Faculty of Science, University of Zagreb, Horvatovac 102a, HR-10000, Zagreb, Croatia.
Laboratory for Magnetic Resonances, Division of Physical Chemistry, Ruđer Bošković Institute, Bijenička 54, HR-10000 Zagreb, Croatia.
Heliyon. 2022 Jun 3;8(6):e09556. doi: 10.1016/j.heliyon.2022.e09556. eCollection 2022 Jun.
Solution-based and solid-state reactions of copper(ii) compounds, 1,10-phenanthroline and l-threonine were investigated. Eight new ternary coordination compounds were obtained: [Cu(l-Thr)(HO)(phen)]SO∙10HO ( ), [Cu(l-Thr)(HO) (phen)]SO∙4.3HO ( ), {[Cu(-l-Thr)(phen)]SO∙3.5HO} ( ), [Cu(l-Thr)(HO)(phen)][Cu(l-Thr)(CHOH)(phen)]SO∙2HO∙CHOH ( ), [Cu(l-Thr)(HO)(phen)][Cu(l-Thr)(CHOH)(phen)]SO∙4HO ( , [Cu(l-Thr)(CHOH)(phen)]SO∙HO ( ), [Cu(l-Thr)(HO)(phen)][Cu(l-Thr)(CHOH)(phen)][Cu(SO)(l-Thr)(phen)]HSO∙HO∙3CHOH ( ), [Cu(l-Thr)(HO)(phen)][Cu(l-Thr)(phen)(py)]SO () (phen = 1,10-phenanthroline, l-Thr = l-threoninate, py = pyridine). X-ray crystal structure analysis of the prepared ternary coordination compounds revealed extensive hydrogen bonding and π-interactions that link complex species, anions and solvent molecules into 3D architectures. The water/methanol solvent molecules are found in pockets and/or channels in seven solvates. ESR spectra of different types of compounds were also investigated. In all measured compounds the unpaired electron of the copper(II) ion is located in the d orbital which is in agreement with elongated square-pyramidal geometry. Compound showed substantial cytotoxic activity toward human hepatocellular carcinoma (HepG2) and acute monocytic leukaemia (THP-1) cell lines.
研究了铜（II）化合物、1,10 - 菲咯啉和L - 苏氨酸的溶液法和固态反应。得到了八种新型三元配位化合物：[Cu(l - Thr)(HO)(phen)]SO∙10HO ( )、[Cu(l - Thr)(HO) (phen)]SO∙4.3HO ( )、{[Cu(-l - Thr)(phen)]SO∙3.5HO} ( )、[Cu(l - Thr)(HO)(phen)][Cu(l - Thr)(CHOH)(phen)]SO∙2HO∙CHOH ( )、[Cu(l - Thr)(HO)(phen)][Cu(l - Thr)(CHOH)(phen)]SO∙4HO ( 、[Cu(l - Thr)(CHOH)(phen)]SO∙HO ( )、[Cu(l - Thr)(HO)(phen)][Cu(l - Thr)(CHOH)(phen)][Cu(SO)(l - Thr)(phen)]HSO∙HO∙3CHOH ( )、[Cu(l - Thr)(HO)(phen)][Cu(l - Thr)(phen)(py)]SO ()（phen = 1,10 - 菲咯啉，l - Thr = L - 苏氨酸盐，py = 吡啶）。对制备的三元配位化合物进行X射线晶体结构分析表明，广泛的氢键和π相互作用将配合物物种、阴离子和溶剂分子连接成三维结构。在七种溶剂化物的口袋和/或通道中发现了水/甲醇溶剂分子。还研究了不同类型化合物的电子顺磁共振光谱。在所有测量的化合物中，铜（II）离子的未成对电子位于d轨道，这与拉长的四方锥几何形状一致。化合物 对人肝癌（HepG2）和急性单核细胞白血病（THP - 1）细胞系表现出显著的细胞毒性活性。
