Solvent effects on the crystallization and structure of ternary copper(ii) coordination compounds with l-threonine and 1,10-phenanthroline.

Solution-based and solid-state reactions of copper(ii) compounds, 1,10-phenanthroline and l-threonine were investigated. Eight new ternary coordination compounds were obtained: [Cu(l-Thr)(HO)(phen)]SO∙10HO ( ), [Cu(l-Thr)(HO) (phen)]SO∙4.3HO ( ), {[Cu(-l-Thr)(phen)]SO∙3.5HO} ( ), [Cu(l-Thr)(HO)(phen)][Cu(l-Thr)(CHOH)(phen)]SO∙2HO∙CHOH ( ), [Cu(l-Thr)(HO)(phen)][Cu(l-Thr)(CHOH)(phen)]SO∙4HO ( , [Cu(l-Thr)(CHOH)(phen)]SO∙HO ( ), [Cu(l-Thr)(HO)(phen)][Cu(l-Thr)(CHOH)(phen)][Cu(SO)(l-Thr)(phen)]HSO∙HO∙3CHOH ( ), [Cu(l-Thr)(HO)(phen)][Cu(l-Thr)(phen)(py)]SO () (phen = 1,10-phenanthroline, l-Thr = l-threoninate, py = pyridine). X-ray crystal structure analysis of the prepared ternary coordination compounds revealed extensive hydrogen bonding and π-interactions that link complex species, anions and solvent molecules into 3D architectures. The water/methanol solvent molecules are found in pockets and/or channels in seven solvates. ESR spectra of different types of compounds were also investigated. In all measured compounds the unpaired electron of the copper(II) ion is located in the d orbital which is in agreement with elongated square-pyramidal geometry. Compound showed substantial cytotoxic activity toward human hepatocellular carcinoma (HepG2) and acute monocytic leukaemia (THP-1) cell lines.