阿戈美拉汀可提高抑郁症患者血清脑源性神经营养因子水平，且与抑郁症状的改善相关。
Agomelatine Increases BDNF Serum Levels in Depressed Patients in Correlation with the Improvement of Depressive Symptoms.
作者信息
Martinotti Giovanni, Pettorruso Mauro, De Berardis Domenico, Varasano Paola Annunziata, Lucidi Pressanti Gabriella, De Remigis Valeria, Valchera Alessandro, Ricci Valerio, Di Nicola Marco, Janiri Luigi, Biggio Giovanni, Di Giannantonio Massimo
机构信息
Department of Neuroscience, Imaging, and Clinical Sciences, University "G.d'Annunzio", Chieti, Italy (Drs Martinotti, De Berardis, and Di Giannantonio); Institute of Psychiatry and Psychology, Catholic University of the Sacred Hearth, Rome, Italy (Drs Pettorruso, Di Nicola, and Janiri); Department of Immunohematology and Transfusional Medicine, "G. Mazzini" Hospital, Teramo, Italy (Drs Varasano, Lucidi Pressanti, and De Remigis); Hermanas Hospitalarias, FoRiPsi, Villa S. Giuseppe Hospital, Ascoli Piceno, Italy (Dr Valchera); Department of Psychiatry, ASL Valle d'Aosta, Italy (Dr Ricci); Department of Life and Environmental Sciences, Institute of Neuroscience, CNR, University of Cagliari, Cagliari, Italy (Dr Biggio).
出版信息
Int J Neuropsychopharmacol. 2016 Apr 29;19(5). doi: 10.1093/ijnp/pyw003. Print 2016 May.
BACKGROUND
Agomelatine modulates brain-derived neurotrophic factor expression via its interaction with melatonergic and serotonergic receptors and has shown promising results in terms of brain-derived neurotrophic factor increase in animal models.
METHODS
Twenty-seven patients were started on agomelatine (25mg/d). Venous blood was collected and brain-derived neurotrophic factor serum levels were measured at baseline and after 2 and 8 weeks along with a clinical assessment, including Hamilton Depression Rating Scale and Snaith-Hamilton Pleasure Scale.
RESULTS
Brain-derived neurotrophic factor serum concentration increased after agomelatine treatment. Responders showed a significant increase in brain-derived neurotrophic factor levels after 2 weeks of agomelatine treatment; no difference was observed in nonresponders. Linear regression analysis showed that more prominent brain-derived neurotrophic factor level variation was associated with lower baseline BDNF levels and greater anhedonic features at baseline.
CONCLUSIONS
Patients affected by depressive disorders showed an increase of brain-derived neurotrophic factor serum concentration after a 2-week treatment with agomelatine. The increase of brain-derived neurotrophic factor levels was found to be greater in patients with lower brain-derived neurotrophic factor levels and marked anhedonia at baseline.
背景
阿戈美拉汀通过与褪黑素能和5-羟色胺能受体相互作用来调节脑源性神经营养因子的表达，并且在动物模型中已显示出在增加脑源性神经营养因子方面有良好的结果。
方法
27例患者开始服用阿戈美拉汀（25mg/天）。在基线时、2周和8周后采集静脉血并测量脑源性神经营养因子的血清水平，同时进行临床评估，包括汉密尔顿抑郁量表和斯奈斯-汉密尔顿愉悦量表。
结果
阿戈美拉汀治疗后脑源性神经营养因子血清浓度升高。有反应者在阿戈美拉汀治疗2周后脑源性神经营养因子水平显著升高；无反应者未观察到差异。线性回归分析表明，更显著的脑源性神经营养因子水平变化与较低的基线脑源性神经营养因子水平和基线时更明显的快感缺失特征相关。
结论
抑郁症患者在接受阿戈美拉汀2周治疗后，脑源性神经营养因子血清浓度升高。发现基线时脑源性神经营养因子水平较低且有明显快感缺失的患者，其脑源性神经营养因子水平升高幅度更大。
Zotero 插件