Cavanah Aidan M, Robinson Laura A, Mattingly Madison L, Frugé Andrew D
College of Nursing, Auburn University, 710 S. Donahue Drive, Auburn, AL 36849, USA.
Department of Nutritional Sciences, Auburn University, 210 Spidle Hall, Auburn, AL 36849, USA.
Biomedicines. 2025 Jul 7;13(7):1656. doi: 10.3390/biomedicines13071656.
: Mood disorders include symptoms of depression, anxiety, and or stress, and have increased in prevalence. Green tea and its bioactive components (epigallocatechin gallate [EGCG] and L-theanine) have been investigated for their health benefits and neuroprotective properties. As adults seek integrative and alternative treatment modalities, it is relevant to determine the effects of natural and non-pharmacological treatments on humans. This study aimed to assess current evidence from published randomized controlled trials testing the effects of green tea, green tea extracts, or its bioactive compounds on mood disorder symptomology and brain-derived neurotrophic factor (BDNF). : We searched PubMed, Cochrane Library, PsycINFO, Embase, Google Scholar, and ClinicalTrials.gov, following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) checklist and utilizing predetermined inclusion and exclusion criteria. : A total of 445 studies were identified, 395 screened, and thirteen met inclusion criteria. Seven used one of the bioactive compounds found in green tea for intervention, while six used green tea extract, matcha, or traditional green tea. Mood disturbance was assessed with several tools, with studies reporting improvements in depressive (n = 4), anxiety (n = 6), stress (n = 5), and sleep (n = 1) symptoms. No studies found a statistically significant effect of green tea or its bioactive compounds on BDNF. Conclusions: Our findings suggest green tea, GTE, L-theanine, and EGCG may improve mood disorder symptomology, particularly symptoms of depression; no evidence to date reports effects on BDNF.
情绪障碍包括抑郁、焦虑和/或压力症状，且患病率有所上升。绿茶及其生物活性成分（表没食子儿茶素没食子酸酯[EGCG]和L-茶氨酸）因其对健康的益处和神经保护特性而受到研究。由于成年人寻求综合和替代治疗方式，确定天然和非药物治疗对人类的影响具有重要意义。本研究旨在评估已发表的随机对照试验的现有证据，这些试验测试了绿茶、绿茶提取物或其生物活性化合物对情绪障碍症状学和脑源性神经营养因子（BDNF）的影响。我们按照系统评价和Meta分析的首选报告项目（PRISMA）清单，利用预先确定的纳入和排除标准，检索了PubMed、Cochrane图书馆、PsycINFO、Embase、谷歌学术和ClinicalTrials.gov。共识别出445项研究，筛选了395项，13项符合纳入标准。7项使用绿茶中发现的一种生物活性化合物进行干预，6项使用绿茶提取物、抹茶或传统绿茶。使用多种工具评估情绪障碍，研究报告抑郁（n = 4）、焦虑（n = 6）、压力（n = 5）和睡眠（n = 1）症状有所改善。没有研究发现绿茶或其生物活性化合物对BDNF有统计学上的显著影响。结论：我们的研究结果表明，绿茶、绿茶提取物、L-茶氨酸和EGCG可能改善情绪障碍症状学，尤其是抑郁症状；迄今为止，没有证据表明对BDNF有影响。
