Zhang G, Liu Z, Qin S, Li K
Eur J Gynaecol Oncol. 2015;36(6):629-32.
Cancer is a group of diseases characterized by uncontrolled growth and spread of abnormal cells. If the spread is not con-trolled, it can result in death. Sirtunins belong to a protein family and it is present in all organisms. SIRT6 is downregulated in tumor and acts as tumor suppressor. These sirtunin proteins are linked to repair DNA and metabolism.
To measure the role of SIRT6 in tumor cell, 20 mice were used and European Collection of Cell Cultures (ECACC) cell lines were used for the analysis. A histopathological technique showed the level of tumor cells.
A recent study provided exceptional insight into the mechanism of SIRT6-related chromatin regulation. According to the histopathology of cancer, SIRT1 localizes to the promoters of several aberrantly silenced tumor suppressor genes whose DNA is hypermethylated. SIRT1 has a role associated with the epigenetic hallmarks of cancer.
The link between SIRT6 and cancer provide new insight into the therapeutic potential of small molecule activators or specific targets of SIRT6 for the prevention and treatment of cancer. Further investigation into the specific mechanism of SIRT6 is required to realize this potential.
癌症是一组以异常细胞不受控制地生长和扩散为特征的疾病。如果这种扩散得不到控制，可能会导致死亡。沉默调节蛋白属于一个蛋白质家族，存在于所有生物体中。SIRT6在肿瘤中表达下调，并起到肿瘤抑制作用。这些沉默调节蛋白与DNA修复和代谢有关。
为了测定SIRT6在肿瘤细胞中的作用，使用了20只小鼠，并使用欧洲细胞培养物保藏中心（ECACC）的细胞系进行分析。一种组织病理学技术显示了肿瘤细胞的水平。
最近的一项研究对SIRT6相关的染色质调控机制提供了独特的见解。根据癌症的组织病理学，SIRT1定位于几个DNA发生高甲基化的异常沉默的肿瘤抑制基因的启动子区域。SIRT1具有与癌症的表观遗传特征相关的作用。
SIRT6与癌症之间的联系为小分子激活剂或SIRT6的特定靶点在癌症预防和治疗方面的治疗潜力提供了新的见解。需要进一步研究SIRT6的具体机制以实现这一潜力。
