Turk J Med Sci. 2015;45(6):1207-13. doi: 10.3906/sag-1309-62.
BACKGROUND/AIM: Data about contact allergen sensitization (CAS) in children with atopic dermatitis (AD) are limited. The purpose of this study was to identify the frequency and patterns of CAS in children with AD by using a ready-to-use patch test system.
After receiving the history of CAS in the patients, the severity of AD and IgE-mediated allergen sensitization were determined.
Of 134 children with AD, 33.8% (n = 45) had at least 1 positive reaction. The most frequent positive reaction was to nickel sulfate (NS) (37.8%, 17/45), followed by methylchloroisothiazolinone (20.0%, 9/45) and thimerosal (15.6%, 7/45). The total Scoring Atopic Dermatitis (SCORAD) score was significantly higher in the NS-sensitized group (P = 0.036). The patients with NS sensitization had moderate-severe AD more frequently than those without any reaction (P = 0.020). When the SCORAD score was evaluated in detail, extent of eczema, score of sleep loss, and pruritus were significantly higher in the patients with NS sensitization than those without any reaction (P = 0.002, P = 0.001, and P = 0.002, respectively).
Our study confirms the necessity of CAS in the management of AD. In particular, NS sensitization should be considered for children with severe AD or larger extent of eczema and trunk involvement.
背景/目的：有关特应性皮炎（AD）患儿接触过敏原致敏（CAS）的数据有限。本研究的目的是使用即用型斑贴试验系统确定 AD 患儿中 CAS 的频率和模式。
在向患者询问 CAS 病史后，确定 AD 的严重程度和 IgE 介导的过敏原致敏情况。
在 134 名 AD 患儿中，有 33.8%（n=45）至少有 1 项阳性反应。最常见的阳性反应是对硫酸镍（NS）（37.8%，17/45），其次是甲基氯异噻唑啉酮（20.0%，9/45）和硫柳汞（15.6%，7/45）。NS 致敏组的总特应性皮炎评分（SCORAD）明显更高（P=0.036）。与无任何反应的患者相比，NS 致敏的患者更常患有中重度 AD（P=0.020）。当详细评估 SCORAD 评分时，NS 致敏患者的湿疹程度、睡眠丧失评分和瘙痒评分明显高于无任何反应的患者（P=0.002，P=0.001 和 P=0.002，分别）。
本研究证实了 AD 管理中 CAS 的必要性。特别是对于严重 AD 或湿疹程度较大和躯干受累的儿童，应考虑 NS 致敏。
