Dinh A, Bouchand F, Salomon J, Bernard L
Unité des maladies infectieuses, hôpitaux universitaires Paris-Île-de-France Ouest, CHU Raymond-Poincaré, 104, boulevard Raymond-Poincaré, 92380 Garches, France.
Service de pharmacie, hôpitaux universitaires Paris-Île-de-France Ouest, CHU Raymond-Poincaré, 104, boulevard Raymond-Poincaré, 92380 Garches, France.
Rev Med Interne. 2016 Jul;37(7):466-72. doi: 10.1016/j.revmed.2015.12.003. Epub 2016 Jan 8.
Antibiotic treatment durations are not well documented. Yet, dramatic emergence of multi-drug resistant organisms should lead to tend to decrease antibiotic selection pressure. Furthermore, it could lower health costs and reduce associated adverse events. Unfortunately, only few studies with rigorous methodology have been performed. We present the available data on frequent infections such as urinary tract infections, community acquired pneumonia, bone and joint infections and intra-abdominal infections. We underline the difficulties to perform such trials and discuss original options to a better evaluation of treatment duration.
抗生素治疗疗程尚无充分记录。然而，多重耐药菌的急剧出现应会导致抗生素选择压力趋于降低。此外，这还可降低医疗成本并减少相关不良事件。遗憾的是，仅有少数采用严格方法的研究得以开展。我们展示了关于常见感染（如尿路感染、社区获得性肺炎、骨与关节感染以及腹腔内感染）的现有数据。我们强调了进行此类试验的困难，并讨论了用于更好评估治疗疗程的新方法。
