黑色素浓缩激素。二、黑色素浓缩激素的结构与生物合成。

Melanin concentrating hormone. II. Structure and biosynthesis of melanin-concentrating hormone.

作者信息

Kawauchi H

机构信息

Laboratory of Molecular Endocrinology, School of Fisheries Sciences, Kitasato University, Iwate, Japan.

出版信息

Life Sci. 1989;45(13):1133-40. doi: 10.1016/0024-3205(89)90500-6.

DOI:10.1016/0024-3205(89)90500-6

PMID:2677572

Abstract

Melanin-concentrating hormone is a neuropeptide produced in teleost hypothalami and transferred to the neurohypophysis. Salmon MCH was a novel cyclic heptadecapeptide capable of inducing melanin aggregation of integumentary melanophores at picoto nano-molar concentrations in all teleosts tested. The MCH gene is intronless and the exon encodes a 132 amino acid precursor protein, in which the heptadecapeptide of MCH locates at the C-terminal end. Immunohistochemical surveys with anti-salmon MCH antiserum strongly suggest that an MCH-like peptide is present in the hypothalami of higher vertebrates. Biological effects of salmon MCH on other vertebrates are found to be versatile.

摘要

促黑素细胞激素是一种在硬骨鱼下丘脑产生并转移至神经垂体的神经肽。鲑鱼促黑素细胞激素是一种新型环状十七肽，在所有受试硬骨鱼中，它能够在皮摩尔至纳摩尔浓度下诱导体表黑素细胞的黑色素聚集。促黑素细胞激素基因无内含子，外显子编码一个132个氨基酸的前体蛋白，其中促黑素细胞激素的十七肽位于C末端。用抗鲑鱼促黑素细胞激素抗血清进行的免疫组织化学研究强烈表明，高等脊椎动物的下丘脑存在一种促黑素细胞激素样肽。已发现鲑鱼促黑素细胞激素对其他脊椎动物具有多种生物学效应。