两种编码大麻哈鱼促黑素细胞激素的信使核糖核酸的结构
Structures of two kinds of mRNA encoding the chum salmon melanin-concentrating hormone.
作者信息
Ono M, Wada C, Oikawa I, Kawazoe I, Kawauchi H
机构信息
Department of Molecular Biology, School of Medicine, Kitasato University, Kanagawa, Japan.
出版信息
Gene. 1988 Nov 30;71(2):433-8. doi: 10.1016/0378-1119(88)90060-1.
The structures of two kinds of melanin-concentrating hormone (MCH) cDNA clones isolated from a chum salmon hypothalamus cDNA library were described. The MCH heptadecapeptide was present at the C terminus of a putative MCH precursor consisting of 132 amino acid residues. The two clones were 80% homologous with each other at the amino acid sequence level. Two genes, each directing one of the mRNAs was noted at about a single copy per haploid salmon genome. MCH genes were efficiently expressed as 0.9-kb poly(A)+RNA in salmon hypothalamus, and sequences hybridizable with salmon MCH cDNA were found in rat hypothalamus.
描述了从银大麻哈鱼下丘脑cDNA文库中分离出的两种黑色素浓缩激素（MCH）cDNA克隆的结构。MCH十七肽存在于由132个氨基酸残基组成的假定MCH前体的C末端。这两个克隆在氨基酸序列水平上彼此同源性为80%。在单倍体鲑鱼基因组中，大约以单拷贝存在两个基因，每个基因指导一种mRNA。MCH基因在鲑鱼下丘脑中高效表达为0.9 kb的聚腺苷酸加尾RNA（poly(A)+RNA），并且在大鼠下丘脑中发现了与鲑鱼MCH cDNA可杂交的序列。
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