胃切除术对转移性胃癌患者生存的影响：ASMO研究

The effect of the gastrectomy on survival in patients with metastatic gastric cancer: a study of ASMO.

作者信息

Yazıcı Ozan, Özdemir Nuriye, Duran Ayşe Ocak, Menekşe Serkan, Şendur Mehmet Ali, Karaca Halit, Göksel Gamze, Arpacı Erkan, Hacıbekiroğlu İlhan, Bilgetekin İrem, Kaçan Turgut, Özkan Metin, Aksoy Sercan, Aksoy Asude, Çokmert Suna, Uysal Mükremin, Elkıran Emin Tamer, Çiçin İrfan, Büyükberber Süleyman, Zengin Nurullah

机构信息

Ankara Numune Education & Research Hospital, Department of Medical Oncology, Sihhiye 06410, Ankara, Turkey.

Yıldırım Beyazıt University Faculty of Medicine, Department of Medical Oncology, Bilkent Avenue 06800, Ankara, Turkey.

出版信息

Future Oncol. 2016 Feb;12(3):343-54. doi: 10.2217/fon.15.304. Epub 2016 Jan 18.

DOI:10.2217/fon.15.304

PMID:26775722

Abstract

AIM

To investigate the role of surgical resection of primary tumor on overall survival (OS) in advanced gastric cancer patients at the time of diagnosis.

PATIENTS & METHODS: The survival rates of metastatic gastric cancer patients whose gastric primary tumor was resected at time of diagnosis were compared with metastatic gastric cancer patients whose primary tumor was nonresected.

RESULTS

The median progression-free survival and OS in operated and nonoperated group were 10 versus 6, 14 versus 9 months, respectively (p < 0.001). In multivariate analysis, gastric resection of primary tumor, Eastern Cooperative Oncology Group performance status, second-line chemotherapy had a significant effect on OS (hazard ratio [HR]: 0.52 [95% CI: 0.38-0.71], HR: 0.57 [95% CI: 0.42-0.78], HR: 1.48 [1.09-2.01]; p ≤ 0.001, p = 0.001 and p = 0.012, respectively).

CONCLUSION

Subpopulations of patients with metastatic gastric cancer might benefit from surgical removal of primary tumor.

摘要

目的

探讨在晚期胃癌患者诊断时手术切除原发肿瘤对总生存期（OS）的作用。

患者与方法

将诊断时胃原发肿瘤已切除的转移性胃癌患者的生存率与原发肿瘤未切除的转移性胃癌患者进行比较。

结果

手术组和未手术组的无进展生存期和总生存期的中位数分别为10个月对6个月、14个月对9个月（p<0.001）。多因素分析显示，原发肿瘤的胃切除术、东部肿瘤协作组体能状态、二线化疗对总生存期有显著影响（风险比[HR]：0.52[95%置信区间：0.38 - 0.71]，HR：0.57[95%置信区间：0.42 - 0.78]，HR：1.48[1.09 - 2.01]；p≤0.001、p = 0.001和p = 0.012）。