Odat Ramez M, Idrees Muhammad, Marsool Mohammed Dheyaa Marsool, Oglat Shahed Mamoun, Tbayshat Salma Omar, Adnan Zaid Ibrahim, Alkhateeb Yousef Adeeb, Aldamen Ali O, Jain Hritvik, Nguyen Dang, Hanifa Hamdah
Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan.
Lahore General Hospital, Lahore, Punjab, Pakistan.
Int J Emerg Med. 2024 Dec 27;17(1):199. doi: 10.1186/s12245-024-00795-y.
Non-cancer deaths are now becoming a significant threat to the health of cancer patients. Death from stomach and duodenal ulcer is linked to cancer due to the side effects of treatment and its pathogenesis. However, guidelines for identifying cancer patients at the highest risk of death from stomach and duodenal ulcer remain unclear.
Data of all patients diagnosed with cancer between 2000 and 2021 were obtained from the Surveillance, Epidemiology, and End Results (SEER) database. Data regarding the causes of death and clinicopathological features such as sex, age, race, marital status, SEER stage, and treatment procedures were extracted. We calculated standardized mortality ratios (SMRs) using the SEER*Stat software V8.4.3.
Of the 6,891,191 cancer patients, 2,318 died of stomach and duodenal ulcer, a rate higher than that in the general population (SMR = 1.58, 95% CI [1.52-1.65]). Stomach and duodenal ulcer-related deaths decreased over time from 870 deaths between 2000 and 2004 to 294 deaths between 2015 and 2019. Among the 2,318 stomach and duodenal ulcer deaths, the highest numbers were observed in patients with prostate cancer (n = 389, 16.8%), and lung and bronchus cancer (n = 255, 11%). Patients with liver and intrahepatic bile duct cancers (SMR = 10.53, 95% CI [8.3-13.18]), and pancreatic cancer (SMR = 6.84, 95% CI [5.11-8.97]) had a significantly higher rate of death from stomach and duodenal ulcer than the general population.
Our study revealed a significantly higher risk of stomach and duodenal ulcer mortality among patients with cancer in the United States, underscoring the critical need for integrated care strategies that address both cancer and ulcer-related complications. To reduce ulcer-related mortality, we recommend the implementation of targeted prevention protocols, including routine gastrointestinal screenings for high-risk cancer patients, proactive management of ulcer risk factors, and collaboration between oncology, gastroenterology, and surgical teams.
非癌症死亡如今正成为癌症患者健康的重大威胁。胃和十二指肠溃疡导致的死亡与癌症相关，这归因于治疗的副作用及其发病机制。然而，用于识别胃和十二指肠溃疡死亡风险最高的癌症患者的指南仍不明确。
从监测、流行病学和最终结果（SEER）数据库中获取2000年至2021年间所有被诊断为癌症的患者的数据。提取有关死亡原因以及性别、年龄、种族、婚姻状况、SEER分期和治疗程序等临床病理特征的数据。我们使用SEER*Stat软件V8.4.3计算标准化死亡率（SMR）。
在6891191名癌症患者中，2318人死于胃和十二指肠溃疡，这一比率高于普通人群（标准化死亡率=1.58，95%置信区间[1.52 - 1.65]）。胃和十二指肠溃疡相关死亡人数随时间减少，从2000年至2004年的870例死亡降至2015年至2019年的294例死亡。在2318例胃和十二指肠溃疡死亡病例中，前列腺癌患者（n = 389，16.8%）以及肺癌和支气管癌患者（n = 255，11%）的死亡人数最多。肝癌和肝内胆管癌患者（标准化死亡率=10.53，95%置信区间[8.3 - 13.18]）以及胰腺癌患者（标准化死亡率=6.84，95%置信区间[5.11 - 8.97]）死于胃和十二指肠溃疡的比率显著高于普通人群。
我们的研究表明，美国癌症患者中胃和十二指肠溃疡死亡风险显著更高，这凸显了制定综合护理策略以应对癌症和溃疡相关并发症的迫切需求。为降低溃疡相关死亡率，我们建议实施有针对性的预防方案，包括对高危癌症患者进行常规胃肠筛查、积极管理溃疡风险因素，以及肿瘤学、胃肠病学和外科团队之间的协作。
