Whitmire Clarissa J, Waiblinger Christian, Schwarz Cornelius, Stanley Garrett B
Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA 30332, USA.
Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA 30332, USA; Systems Neurophysiology, Werner Reichardt Centre for Integrative Neuroscience, University of Tübingen, Tübingen 72074, Germany; Department of Cognitive Neurology, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen 72074, Germany.
Cell Rep. 2016 Feb 2;14(4):795-807. doi: 10.1016/j.celrep.2015.12.068. Epub 2016 Jan 14.
It has been posited that the regulation of burst/tonic firing in the thalamus could function as a mechanism for controlling not only how much but what kind of information is conveyed to downstream cortical targets. Yet how this gating mechanism is adaptively modulated on fast timescales by ongoing sensory inputs in rich sensory environments remains unknown. Using single-unit recordings in the rat vibrissa thalamus (VPm), we found that the degree of bottom-up adaptation modulated thalamic burst/tonic firing as well as the synchronization of bursting across the thalamic population along a continuum for which the extremes facilitate detection or discrimination of sensory inputs. Optogenetic control of baseline membrane potential in thalamus further suggests that this regulation may result from an interplay between adaptive changes in thalamic membrane potential and synaptic drive from inputs to thalamus, setting the stage for an intricate control strategy upon which cortical computation is built.
有人提出，丘脑爆发式/紧张性放电的调节不仅可以作为一种控制传递到下游皮质靶区的信息量的机制，还可以控制传递何种信息。然而，在丰富的感觉环境中，这种门控机制如何通过持续的感觉输入在快速时间尺度上进行适应性调节，仍然未知。通过在大鼠触须丘脑（腹后内侧核，VPm）进行单单元记录，我们发现自下而上的适应程度会沿着一个连续体调节丘脑爆发式/紧张性放电以及丘脑群体中爆发的同步性，在这个连续体中，极端情况有利于感觉输入的检测或辨别。对丘脑基线膜电位的光遗传学控制进一步表明，这种调节可能源于丘脑膜电位的适应性变化与丘脑输入的突触驱动之间的相互作用，为构建皮质计算的复杂控制策略奠定了基础。
