Bascom Alexandra, Ghosh Sunita, Fairey Adrian S, Rourke Keith F
Division of Urology, Department of Surgery, University of Alberta, Edmonton, Alberta, Canada.
Division of Urology, Department of Surgery, University of Alberta, Edmonton, Alberta, Canada.
Urology. 2016 Apr;90:184-8. doi: 10.1016/j.urology.2015.12.047. Epub 2016 Jan 8.
To analyze risk factors for wound-specific complications after bulbar urethroplasty, including the association between incision type and complications.
This is a retrospective review of 829 urethroplasties excluding penile strictures, incomplete data sets, and radiation-induced urethral stenosis. Ninety-day wound complications were reported using the modified Clavien-Dindo classification of postoperative complications. Risk factors for wound complications were evaluated using univariable and multivariable analysis: patient age, positive preoperative urine culture, Charlson comorbidity index ≥ 2, diabetes, body mass index ≥ 35, smoking, and incision type (lambda perineal incision [LPI] vs. midline perineal incision [MPI]).
Five hundred forty patients met inclusion criteria; 373 patients with an LPI and 167 patients with an MPI. Ninety-day wound complications (any Clavien grade) occurred in 21% of patients. Multivariable analyses indicated that incision type alone was significantly associated with wound complications (multivariable: MPI OR 0.53 (0.34-0.83), P = .01). The majority of complications were Clavien ≤ 2, which occurred in 23.3% (87 patients) of LPIs compared to 11.9% (20 patients) of MPIs (P = .002). The primary difference between the incisions was superficial wound edge separation (LPI 10.7% [40 patients]; MPI 0%, P < .0001). Early (6-month) urethroplasty success favored the midline incision (LPI 6.2% vs MPI 0%, P = .0003), implying no obvious technical advantage for the lambda incision. Study limitations include a retrospective design and the use of some patient-reported complication outcomes.
An LPI is independently associated with increased 90-day wound complications after urethroplasty, with no identifiable advantage in urethroplasty outcome.
分析球部尿道成形术后伤口特异性并发症的危险因素,包括切口类型与并发症之间的关联。
这是一项对829例尿道成形术的回顾性研究,排除阴茎狭窄、数据集不完整以及放射性尿道狭窄病例。采用改良的Clavien-Dindo术后并发症分类法报告90天伤口并发症情况。使用单变量和多变量分析评估伤口并发症的危险因素:患者年龄、术前尿培养阳性、Charlson合并症指数≥2、糖尿病、体重指数≥35、吸烟以及切口类型(λ型会阴切口[LPI]与中线会阴切口[MPI])。
540例患者符合纳入标准;373例采用LPI,167例采用MPI。21%的患者发生了90天伤口并发症(任何Clavien分级)。多变量分析表明,仅切口类型与伤口并发症显著相关(多变量分析:MPI比值比0.53[0.34 - 0.83],P = 0.01)。大多数并发症为Clavien≤2级,LPI组发生率为23.3%(87例),而MPI组为11.9%(20例)(P = 0.002)。两种切口的主要差异在于浅表伤口边缘分离(LPI为10.7%[40例];MPI为0%,P < 0.0001)。早期(术后6个月)尿道成形术成功率中线切口更优(LPI为6.2%,MPI为0%,P = 0.0003),这表明λ切口无明显技术优势。研究局限性包括回顾性设计以及部分患者报告的并发症结局。
LPI与尿道成形术后90天伤口并发症增加独立相关,在尿道成形术结局方面无明显优势。