Erek Ersin, Aydin Selim, Suzan Dilek, Yildiz Okan, Demir Ibrahim Halil, Odemis Ender
Acibadem University, Medical Faculty, Acibadem Atakent Hospital, Halkali, Istanbul, Turkey.
Acibadem University, Medical Faculty, Acibadem Atakent Hospital, Halkali, Istanbul, Turkey.
Ann Thorac Surg. 2016 Feb;101(2):758-60. doi: 10.1016/j.athoracsur.2015.04.051.
The use of prosthetic patch material is often required during the surgical reconstruction of complex congenital cardiac malformations. Decellularized porcine small intestinal submucosa, a type of extracellular matrix, was recently introduced as a patch for cardiac and vascular tissue repair. Extracellular matrix was used for aortic reconstruction during the Norwood procedure in 8 consecutive neonates with hypoplastic left heart syndrome. Rapid degeneration or aneurysm formation developed in 3 of these patients who came to second-stage surgery. Extracellular matrix should be used cautiously for aortic reconstruction in infants until additional reports from other centers provide confirmation of its safety.
在复杂先天性心脏畸形的手术重建过程中，常常需要使用人工补片材料。脱细胞猪小肠黏膜下层作为一种细胞外基质，最近被引入用于心脏和血管组织修复的补片。细胞外基质被用于8例连续的左心发育不全综合征新生儿的诺伍德手术中的主动脉重建。在接受二期手术的这些患者中，有3例出现了快速退变或动脉瘤形成。在其他中心提供更多安全性确认报告之前，细胞外基质在婴儿主动脉重建中的使用应谨慎。
