Yang Hyuk In, Kim Hyeon Chang, Jeon Justin Y
Exercise Medicine Center for Diabetes and Cancer Patients, ICONS, Yonsei University, Seoul, Republic of Korea; Department of Sport and Leisure Studies, Yonsei University, Seoul, Republic of Korea.
Cardiovascular and Metabolic Diseases Etiology Research Center, Yonsei University, Seoul, Republic of Korea; Department of Preventive Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea.
Clin Chim Acta. 2016 Apr 1;455:195-200. doi: 10.1016/j.cca.2016.01.006. Epub 2016 Jan 9.
Investigate the association of resting heart rate (RHR) with diabetes, hypertension and metabolic syndrome in a data set that represents the whole Korean adult population.
The data of 18,640 adults, that represent the whole Korean adult population, was used to examine the association of resting heart rate (RHR) with blood related variables, diabetes, hypertension and metabolic syndrome.
Compared to participants with a RHR of <60 beats per minute (bpm), participants with a RHR of ≥90 bpm had higher odds of diabetes {3.85 [95% confidence interval (CI) 2.14-6.90], 3.34 (95% CI 1.83-6.10)} and metabolic syndrome [3.55 (95% CI 2.19-5.74), 2.15 (95% CI 1.37-3.35)], for men and women, respectively. Furthermore, compared to the participants with normal BMI (<23 kg/m(2)) normal RHR (<80 bpm), participants with high BMI (≥23 kg/m(2)) high RHR (≥80 bpm) had higher odds of diabetes [2.51 (95% CI 1.83-3.46), 4.89 (95% CI 3.63-6.58)], hypertension [3.88 (95% CI 3.00-5.01), 2.61 (95% CI 2.07-3.28)], and metabolic syndrome [9.67 (95% CI 7.42-12.61), 13.09 (95% CI 10.25-16.73)], for men and women, respectively. RHR shows a positive dose response relationship with the prevalence of diabetes and metabolic syndrome. The combined association of RHR with BMI increases the potency of RHR as a marker of diabetes, hypertension and metabolic syndrome.
This study shows that RHR has an important role to play as a potential clinical measurement and prognostic marker.
在一个代表韩国全体成年人口的数据集里，研究静息心率（RHR）与糖尿病、高血压及代谢综合征之间的关联。
使用代表韩国全体成年人口的18640名成年人的数据，来检验静息心率（RHR）与血液相关变量、糖尿病、高血压及代谢综合征之间的关联。
与静息心率小于60次/分钟（bpm）的参与者相比，静息心率大于等于90次/分钟（bpm）的参与者患糖尿病的几率更高{男性为3.85[95%置信区间（CI）2.14 - 6.90]，女性为3.34（95%CI 1.83 - 6.10）}，患代谢综合征的几率也更高[男性为3.55（95%CI 2.19 - 5.74），女性为2.15（95%CI 1.37 - 3.35）]。此外，与体重指数正常（<23kg/m²）且静息心率正常（<80bpm）的参与者相比，体重指数高（≥23kg/m²）且静息心率高（≥80bpm）的参与者患糖尿病的几率更高[男性为2.51（95%CI 1.83 - 3.46），女性为4.89（95%CI 3.63 - 6.58）]，患高血压的几率更高[男性为3.88（95%CI 3.00 - 5.01），女性为2.61（95%CI 2.07 - 3.28）]，患代谢综合征的几率更高[男性为9.67（95%CI 7.42 - 12.61），女性为13.09（95%CI 10.25 - 16.73）]。静息心率与糖尿病和代谢综合征的患病率呈正剂量反应关系。静息心率与体重指数的联合关联增加了静息心率作为糖尿病、高血压和代谢综合征标志物的效力。
本研究表明，静息心率作为一种潜在的临床测量指标和预后标志物具有重要作用。
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