雌激素在调节血管健康中的分子作用。
The molecular actions of oestrogen in the regulation of vascular health.
作者信息
Usselman Charlotte W, Stachenfeld Nina S, Bender Jeffrey R
机构信息
Faculty of Physical Education and Recreation, University of Alberta, Edmonton, AB, Canada.
The John B. Pierce Laboratory, Yale School of Medicine, New Haven, CT, USA.
出版信息
Exp Physiol. 2016 Mar;101(3):356-61. doi: 10.1113/EP085148.
What is the topic of this review? This review summarizes the beneficial actions of oestrogen on the vasculature, highlighting both molecular mechanisms and functional outcomes. What advances does it highlight? The net effect of oestrogen on the vascular health of women continues to be debated. Recent advances have provided strong evidence for the role of membrane-bound oestrogen receptors in the maintenance of normal endothelial function. On a broader scale, functional outcomes of oestrogen actions on the vasculature may mediate the reduced risk of cardiovascular disease in premenopausal women. The conflicting implications of the large-scale clinical menopausal hormone therapy trials in humans versus the findings of studies on experimental animals underscore the limitations within our understanding of the molecular actions of oestrogen. However, recent research has provided improved insight into the actions of oestrogen on the endothelium and vascular smooth muscle. This review outlines the actions of oestrogen as it contributes to vascular structure, function and health.
本综述的主题是什么？本综述总结了雌激素对血管系统的有益作用，重点介绍了分子机制和功能结果。它突出了哪些进展？雌激素对女性血管健康的净效应仍存在争议。最近的进展为膜结合雌激素受体在维持正常内皮功能中的作用提供了有力证据。从更广泛的角度来看，雌激素作用于血管系统的功能结果可能介导了绝经前女性心血管疾病风险的降低。大规模临床绝经激素治疗试验在人体中的矛盾结果与实验动物研究的结果凸显了我们对雌激素分子作用理解的局限性。然而，最近的研究对雌激素作用于内皮和血管平滑肌有了更深入的了解。本综述概述了雌激素在促进血管结构、功能和健康方面的作用。
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