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锥体神经元探索器：一种探索人类锥体神经元形态-功能关系的新型交互式工具。

PyramidalExplorer: A New Interactive Tool to Explore Morpho-Functional Relations of Human Pyramidal Neurons.

作者信息

Toharia Pablo, Robles Oscar D, Fernaud-Espinosa Isabel, Makarova Julia, Galindo Sergio E, Rodriguez Angel, Pastor Luis, Herreras Oscar, DeFelipe Javier, Benavides-Piccione Ruth

机构信息

Universidad Rey Juan CarlosMadrid, Spain; Center for Computational Simulation, Universidad Politécnica de MadridMadrid, Spain.

Laboratorio Cajal de Circuitos Corticales, Centro de Tecnología Biomédica, Universidad Politécnica de Madrid Madrid, Spain.

出版信息

Front Neuroanat. 2016 Jan 6;9:159. doi: 10.3389/fnana.2015.00159. eCollection 2015.

DOI:10.3389/fnana.2015.00159
PMID:26778972
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4701943/
Abstract

This work presents PyramidalExplorer, a new tool to interactively explore and reveal the detailed organization of the microanatomy of pyramidal neurons with functionally related models. It consists of a set of functionalities that allow possible regional differences in the pyramidal cell architecture to be interactively discovered by combining quantitative morphological information about the structure of the cell with implemented functional models. The key contribution of this tool is the morpho-functional oriented design that allows the user to navigate within the 3D dataset, filter and perform Content-Based Retrieval operations. As a case study, we present a human pyramidal neuron with over 9000 dendritic spines in its apical and basal dendritic trees. Using PyramidalExplorer, we were able to find unexpected differential morphological attributes of dendritic spines in particular compartments of the neuron, revealing new aspects of the morpho-functional organization of the pyramidal neuron.

摘要

这项工作展示了PyramidalExplorer，这是一种新工具，可通过功能相关模型交互式地探索和揭示锥体神经元微观解剖结构的详细组织。它由一组功能组成，通过将有关细胞结构的定量形态信息与已实现的功能模型相结合，能够交互式地发现锥体细胞结构中可能存在的区域差异。该工具的关键贡献在于其形态功能导向设计，允许用户在三维数据集中导航、过滤并执行基于内容的检索操作。作为一个案例研究，我们展示了一个在其顶端和基部树突中具有9000多个树突棘的人类锥体神经元。使用PyramidalExplorer，我们能够在神经元的特定隔室中发现树突棘意外的差异形态属性，揭示了锥体神经元形态功能组织的新方面。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/440c/4701943/7dce065a9770/fnana-09-00159-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/440c/4701943/0935fe1028a4/fnana-09-00159-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/440c/4701943/b51c9818a7c9/fnana-09-00159-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/440c/4701943/5df717ae838b/fnana-09-00159-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/440c/4701943/b1fd10db81bf/fnana-09-00159-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/440c/4701943/7dce065a9770/fnana-09-00159-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/440c/4701943/0935fe1028a4/fnana-09-00159-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/440c/4701943/b51c9818a7c9/fnana-09-00159-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/440c/4701943/5df717ae838b/fnana-09-00159-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/440c/4701943/b1fd10db81bf/fnana-09-00159-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/440c/4701943/7dce065a9770/fnana-09-00159-g005.jpg

相似文献

[1]
PyramidalExplorer: A New Interactive Tool to Explore Morpho-Functional Relations of Human Pyramidal Neurons.

Front Neuroanat. 2016-1-6

[2]
Three-dimensional spatial modeling of spines along dendritic networks in human cortical pyramidal neurons.

PLoS One. 2017-6-29

[3]
3D morphology-based clustering and simulation of human pyramidal cell dendritic spines.

PLoS Comput Biol. 2018-6-13

[4]
The occipitoparietal pathway of the macaque monkey: comparison of pyramidal cell morphology in layer III of functionally related cortical visual areas.

Cereb Cortex. 1997

[5]
Comprehensive Morpho-Electrotonic Analysis Shows 2 Distinct Classes of L2 and L3 Pyramidal Neurons in Human Temporal Cortex.

Cereb Cortex. 2017-11-1

[6]
Morphological variation of layer III pyramidal neurones in the occipitotemporal pathway of the macaque monkey visual cortex.

Cereb Cortex. 1998

[7]
[Quantitative studies of layer III pyramidal cells of the cingulate cortex of the rat].

Z Mikrosk Anat Forsch. 1980

[8]
Synchronous development of pyramidal neuron dendritic spines and parvalbumin-immunoreactive chandelier neuron axon terminals in layer III of monkey prefrontal cortex.

Neuroscience. 1995-7

[9]
Distribution of synapses on an intracellularly labeled small pyramidal neuron in the cat motor cortex.

Anat Embryol (Berl). 1991

[10]
[Quantitative studies on the dendritic spine distribution on the lamina-5 pyramidal cells in the anterior gyrus cinguli of the rat].

J Hirnforsch. 1976

引用本文的文献

[1]
Theoretical considerations and supporting evidence for the primary role of source geometry on field potential amplitude and spatial extent.

Front Cell Neurosci. 2023-3-30

[2]
The Subcortical-Allocortical- Neocortical for the Emergence and Morphological Heterogeneity of Pyramidal Neurons in the Human Brain.

Front Synaptic Neurosci. 2021-3-11

[3]
InTool Explorer: An Interactive Exploratory Analysis Tool for Versatile Visualizations of Neuroscientific Data.

Front Neuroanat. 2019-3-11

[4]
A Method for the Symbolic Representation of Neurons.

Front Neuroanat. 2018-12-18

[5]
Comments and General Discussion on "The Anatomical Problem Posed by Brain Complexity and Size: A Potential Solution".

Front Neuroanat. 2016-6-10

本文引用的文献

[1]
New uses of LFPs: Pathway-specific threads obtained through spatial discrimination.

Neuroscience. 2015-12-3

[2]
Activity-dependent dendritic spine neck changes are correlated with synaptic strength.

Proc Natl Acad Sci U S A. 2014-6-30

[3]
Spine neck plasticity regulates compartmentalization of synapses.

Nat Neurosci. 2014-3-23

[4]
Mechanisms underlying subunit independence in pyramidal neuron dendrites.

Proc Natl Acad Sci U S A. 2013-12-19

[5]
ConnectomeExplorer: query-guided visual analysis of large volumetric neuroscience data.

IEEE Trans Vis Comput Graph. 2013-12

[6]
Age-based comparison of human dendritic spine structure using complete three-dimensional reconstructions.

Cereb Cortex. 2012-6-17

[7]
Modeling the spatial reach of the LFP.

Neuron. 2011-12-8

[8]
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Front Syst Neurosci. 2011-9-13

[9]
Dendritic spine pathology in neuropsychiatric disorders.

Nat Neurosci. 2011-3

[10]
Interregional synaptic competition in neurons with multiple STDP-inducing signals.

J Neurophysiol. 2010-12-1

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