Gabbe Belinda J, Simpson Pamela M, Harrison James E, Lyons Ronan A, Ameratunga Shanthi, Ponsford Jennie, Fitzgerald Mark, Judson Rodney, Collie Alex, Cameron Peter A
*Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia †The Farr Institute Centre for Improvement of Population Health through E-records Research, College of Medicine, Swansea University, Swansea, UK ‡Research Centre for Injury Studies, Flinders University, Adelaide, South Australia, Australia §Section of Epidemiology and Biostatistics, School of Population Health, University of Auckland, Auckland, New Zealand ¶Monash-Epworth Rehabilitation Research Centre, Melbourne, Australia ||Trauma Service, The Alfred, Melbourne, Australia **Department of Surgery, Monash University, Melbourne, Australia ††Trauma Service, Royal Melbourne Hospital, Parkville, Australia ‡‡Institute for Safety, Compensation and Recovery Research, Monash University, Melbourne, Australia §§Emergency and Trauma Centre, The Alfred, Melbourne, Australia.
Ann Surg. 2016 Apr;263(4):623-32. doi: 10.1097/SLA.0000000000001564.
To describe the long-term outcomes of major trauma patients and factors associated with the rate of recovery.
As injury-related mortality decreases, there is increased focus on improving the quality of survival and reducing nonfatal injury burden.
Adult major trauma survivors to discharge, injured between July 2007 and June 2012 in Victoria, Australia, were followed up at 6, 12, and 24 months after injury to measure function (Glasgow Outcome Scale-Extended) and return to work/study. Random-effects regression models were fitted to identify predictors of outcome and differences in the rate of change in each outcome between patient subgroups.
Among the 8844 survivors, 8128 (92%) were followed up. Also, 23% had achieved a good functional recovery, and 70% had returned to work/study at 24 months. The adjusted odds of reporting better function at 12 months was 27% (adjusted odds ratio 1.27, 95% confidence interval [CI] 1.19-1.36) higher compared with 6 months, and 9% (adjusted odds ratio 1.09, 95% CI, 1.02-1.17) higher at 24 months compared with 12 months. The adjusted relative risk (RR) of returning to work was 14% higher at 12 months compared with 6 months (adjusted RR 1.14, 95% CI, 1.12-1.16) and 8% (adjusted RR 1.08, 95% CI, 1.06-1.10) higher at 24 months compared with 12 months.
Improvement in outcomes over the study period was observed, although ongoing disability was common at 24 months. Recovery trajectories differed by patient characteristics, providing valuable information for informing prognostication and service planning, and improving our understanding of the burden of nonfatal injury.
描述严重创伤患者的长期预后以及与恢复率相关的因素。
随着与损伤相关的死亡率下降,人们越来越关注提高生存质量和减轻非致命性损伤负担。
对2007年7月至2012年6月在澳大利亚维多利亚州受伤并存活至出院的成年严重创伤患者,在受伤后6个月、12个月和24个月进行随访,以评估功能(扩展格拉斯哥预后量表)和恢复工作/学习情况。采用随机效应回归模型确定预后的预测因素以及各患者亚组间各预后变化率的差异。
在8844名幸存者中,8128名(92%)接受了随访。此外,23%的患者实现了良好的功能恢复,70%的患者在24个月时恢复了工作/学习。与6个月时相比,12个月时报告功能改善的校正比值高27%(校正比值比1.27,95%置信区间[CI]1.19 - 1.36),与12个月时相比,24个月时高9%(校正比值比1.09,95% CI 1.02 - 1.17)。与6个月时相比,12个月时恢复工作的校正相对风险(RR)高14%(校正RR 1.14,95% CI 1.12 - 1.16),与12个月时相比,24个月时高8%(校正RR 1.08,95% CI 1.06 - 1.10)。
在研究期间观察到预后有所改善,尽管24个月时仍普遍存在持续残疾。恢复轨迹因患者特征而异,为预后判断和服务规划提供了有价值的信息,并增进了我们对非致命性损伤负担的理解。