Renner Fritz, Arntz Arnoud, Peeters Frenk P M L, Lobbestael Jill, Huibers Marcus J H
MRC Cognition and Brain Sciences Unit, Cambridge, United Kingdom; Department of Clinical Psychological Science, Maastricht University, The Netherlands.
Department of Clinical Psychological Science, Maastricht University, The Netherlands; Department of Clinical Psychology, University of Amsterdam, The Netherlands.
J Behav Ther Exp Psychiatry. 2016 Jun;51:66-73. doi: 10.1016/j.jbtep.2015.12.001. Epub 2015 Dec 8.
The aim of this study was to test the effects of individual schema therapy (ST) for patients with chronic depression.
Using a multiple-baseline single case series design, patients with chronic major depressive disorder (N = 25) first entered a 6-24 weeks baseline phase; this phase functioned as a no-treatment control condition. Then, patients started a 12 week exploration phase during which symptoms and underlying schemas were explored; this phase functioned as an attention control condition. Next, patients received up to 65 sessions of individual ST. The Beck Depression Inventory II (BDI-II) and the Quick Inventory of Depressive Symptomatology (QIDS) were the primary outcome measures. The BDI-II was assessed once a week during all phases of the study resulting in 100 repeated assessments per participant on average. Mixed regression analysis was used to contrast change in symptoms during the intervention with change in symptoms during the baseline and exploration control phases.
When compared to the no-treatment control period, the intervention had a significant, large effect on depressive symptoms (Cohen's d BDI-II = 1.30; Cohen's d QIDS = 1.22). Effects on secondary continuous outcomes were moderate to large.
The small sample size and lack of a control group.
These findings provide evidence that ST might be an effective treatment for patients with chronic depression.
本研究旨在测试个体图式疗法（ST）对慢性抑郁症患者的疗效。
采用多基线单病例系列设计，慢性重度抑郁症患者（N = 25）首先进入为期6 - 24周的基线期；此阶段作为无治疗对照条件。然后，患者开始为期12周的探索期，在此期间探索症状和潜在图式；此阶段作为注意力对照条件。接下来，患者接受多达65次的个体图式疗法治疗。贝克抑郁量表第二版（BDI-II）和抑郁症状快速量表（QIDS）是主要结局指标。在研究的所有阶段，每周对BDI-II进行一次评估，每位参与者平均进行100次重复评估。采用混合回归分析来对比干预期间症状的变化与基线期和探索对照期症状的变化。
与无治疗对照期相比，干预对抑郁症状有显著的、较大的影响（BDI-II的Cohen's d = 1.30；QIDS的Cohen's d = 1.22）。对次要连续结局的影响为中度至较大。
样本量小且缺乏对照组。
这些发现提供了证据，表明图式疗法可能是治疗慢性抑郁症患者的一种有效方法。
