Ke Liangru, Xiang Yanqun, Xia Weixiong, Yang Jing, Yu Yahui, Ye Yanfang, Liang Hu, Guo Xiang, Lv Xing
Department of Nasopharyngeal Carcinoma, Sun Yat-sen University Cancer Center, Guangzhou 510060, PR China; State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Guangzhou 510060, PR China.
Department of Biostatistics and Epidemiology, School of Public Health, Sun Yat-Sen University, Guangzhou 510060, PR China.
Clin Immunol. 2016 Mar;164:45-51. doi: 10.1016/j.clim.2016.01.004. Epub 2016 Jan 15.
Because inflammation plays a critical role in nasopharyngeal carcinoma (NPC), this study aims to investigate the correlation between the pro-inflammation cytokine interleukin-6 (IL6) and the prognosis of NPC and develop a new prognostic model. IL6 levels were measured in the serum of 290 NPC patients by ELISA and the correlation between IL6 and prognosis of NPC was evaluated by Kaplan-Meier analysis and multivariate analysis. The results showed that elevated IL6 levels were positively correlated with poorer 9-year overall survival (OS), disease-free survival (DFS), distant metastasis-free survival (DMFS) and lung metastasis-free survival (lung-MFS). IL6 level was an independent prognostic factor for OS, DFS, DMFS and lung-MFS. The CI-model based on TNM stage and IL6 level could better predict the OS, DFS, DMFS and lung-MFS of NPC patients. Here, the newly developed prognostic CI-model for predicting distant metastasis and death of NPC patients could facilitate patients consulting and individualized immunotherapy.
由于炎症在鼻咽癌（NPC）中起着关键作用，本研究旨在探讨促炎细胞因子白细胞介素-6（IL6）与NPC预后之间的相关性，并建立一种新的预后模型。通过酶联免疫吸附测定（ELISA）法检测了290例NPC患者血清中的IL6水平，并通过Kaplan-Meier分析和多因素分析评估了IL6与NPC预后的相关性。结果显示，IL6水平升高与较差的9年总生存期（OS）、无病生存期（DFS）、无远处转移生存期（DMFS）和无肺转移生存期（肺-MFS）呈正相关。IL6水平是OS、DFS以及DMFS和肺-MFS的独立预后因素。基于TNM分期和IL6水平的CI模型能够更好地预测NPC患者的OS、DFS、DMFS和肺-MFS。在此，新开发的用于预测NPC患者远处转移和死亡的预后CI模型有助于患者咨询和个体化免疫治疗。
