TCM&VIP Inpatient Department, Sun Yat-sen University Cancer Center, Guangzhou, China.
State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China.
Front Immunol. 2024 Oct 17;15:1448012. doi: 10.3389/fimmu.2024.1448012. eCollection 2024.
Nasopharyngeal carcinoma (NPC) is a neoplasm related to inflammation; the expression of cytokines, such as CCL3, CCL4, CCL20, IL-1α, IL-1β, IL-6, IL-8, and IL-10, among others, is presumed to be associated with NPC occurrence and development. Therefore, the circulating levels of these cytokines may be potential biomarkers for assessing tumor aggressiveness, exploring cellular interactions, and monitoring tumor therapeutic responses. Numerous scholars have comprehensively explored the putative mechanisms through which these inflammatory factors affect NPC progression and therapeutic responses. Moreover, investigations have focused on elucidating the correlation between the systemic levels of these cytokines and the incidence and prognosis of NPC. This comprehensive review aims to delineate the advancements in research concerning the relationship between inflammatory factors and NPC while considering their prospective roles as novel prognostic and predictive biomarkers in the context of NPC.
鼻咽癌（NPC）是一种与炎症相关的肿瘤；细胞因子的表达，如 CCL3、CCL4、CCL20、IL-1α、IL-1β、IL-6、IL-8 和 IL-10 等，被认为与 NPC 的发生和发展有关。因此，这些细胞因子的循环水平可能是评估肿瘤侵袭性、探索细胞相互作用和监测肿瘤治疗反应的潜在生物标志物。许多学者已经全面探讨了这些炎症因子影响 NPC 进展和治疗反应的可能机制。此外，研究还集中在阐明这些细胞因子的系统水平与 NPC 的发病率和预后之间的相关性。本综述旨在阐述炎症因子与 NPC 之间关系的研究进展，同时考虑它们作为 NPC 中新型预后和预测生物标志物的潜在作用。
