Sun Xinjuan, Chen Jin'an, Zhang Jie, Wang Wei, Sun Jinshan, Wang Aiping
Department of Endocrinology, The 454th Hospital of PLA, Nanjing, 210002, PR China.
Department of Endocrinology, The 454th Hospital of PLA, Nanjing, 210002, PR China.
J Diabetes Complications. 2016 Mar;30(2):318-22. doi: 10.1016/j.jdiacomp.2015.11.009. Epub 2015 Nov 17.
To determine the role of maggot debridement therapy (MDT) on diabetic foot wound healing, we compared growth related factors in wounds before and after treatment. Furthermore, we utilized human umbilical vein endothelial cells (HUVECs) to explore responses to maggot excretions/secretions on markers of angiogenesis and proliferation. The results showed that there was neo-granulation and angiogenesis in diabetic foot wounds after MDT. Moreover, significant elevation in CD34 and CD68 levels was also observed in treated wounds. In vitro, ES increased HUVEC proliferation, improved tube formation, and increased expression of vascular endothelial growth factor receptor 2 in a dose dependent manner. These results demonstrate that MDT and maggot ES can promote diabetic foot wound healing by up-regulating endothelial cell activity.
为确定蛆虫清创疗法（MDT）对糖尿病足伤口愈合的作用，我们比较了治疗前后伤口中与生长相关的因子。此外，我们利用人脐静脉内皮细胞（HUVECs）来探究蛆虫排泄物/分泌物对血管生成和增殖标志物的反应。结果显示，MDT治疗后糖尿病足伤口出现了新肉芽组织和血管生成。此外，在治疗后的伤口中还观察到CD34和CD68水平显著升高。在体外，蛆虫提取物（ES）以剂量依赖的方式增加了HUVEC的增殖，改善了管腔形成，并增加了血管内皮生长因子受体2的表达。这些结果表明，MDT和蛆虫ES可通过上调内皮细胞活性来促进糖尿病足伤口愈合。
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