2015年的帕金森病：帕金森病不断发展的基础、病理及临床概念 - Suppr

Parkinson disease in 2015: Evolving basic, pathological and clinical concepts in PD.

作者信息

Kalia Lorraine V, Lang Anthony E

机构信息

Krembil Research Institute and the Edmond J. Safra Program in Parkinson's Disease, Toronto Western Hospital, 399 Bathurst Street, Toronto, Ontario M5T 2S8, Canada.

出版信息

Nat Rev Neurol. 2016 Feb;12(2):65-6. doi: 10.1038/nrneurol.2015.249. Epub 2016 Jan 18.

DOI:10.1038/nrneurol.2015.249

PMID:26782330

Abstract

摘要

相似文献

Parkinson disease in 2015: Evolving basic, pathological and clinical concepts in PD.

Nat Rev Neurol. 2016 Feb;12(2):65-6. doi: 10.1038/nrneurol.2015.249. Epub 2016 Jan 18.

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Acta Neuropathol. 2014 Dec;128(6):805-20. doi: 10.1007/s00401-014-1343-6. Epub 2014 Oct 9.

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Nat Rev Neurosci. 2017 Jul;18(7):435-450. doi: 10.1038/nrn.2017.62. Epub 2017 Jun 8.

Pure autonomic failure: a restricted Lewy body synucleinopathy or early Parkinson disease?

Neurology. 2010 Feb 16;74(7):536-7. doi: 10.1212/WNL.0b013e3181d26982.

Biomarkers in Prodromal Parkinson Disease: a Qualitative Review.

J Int Neuropsychol Soc. 2016 Nov;22(10):956-967. doi: 10.1017/S1355617716000503.

Diagnosis and treatment of Parkinson disease: molecules to medicine.

J Clin Invest. 2006 Jul;116(7):1744-54. doi: 10.1172/JCI29178.

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MDS research criteria for prodromal Parkinson's disease.

Mov Disord. 2015 Oct;30(12):1600-11. doi: 10.1002/mds.26431.

MDS clinical diagnostic criteria for Parkinson's disease.

Mov Disord. 2015 Oct;30(12):1591-601. doi: 10.1002/mds.26424.

Parkinson disease and incidental Lewy body disease: Just a question of time?

Neurology. 2015 Nov 10;85(19):1670-9. doi: 10.1212/WNL.0000000000002102. Epub 2015 Oct 14.

α-Synuclein strains cause distinct synucleinopathies after local and systemic administration.

Nature. 2015 Jun 18;522(7556):340-4. doi: 10.1038/nature14547. Epub 2015 Jun 10.

Vagotomy and subsequent risk of Parkinson's disease.

Ann Neurol. 2015 Oct;78(4):522-9. doi: 10.1002/ana.24448. Epub 2015 Jul 17.

Parkinson's disease.

Lancet. 2015 Aug 29;386(9996):896-912. doi: 10.1016/S0140-6736(14)61393-3. Epub 2015 Apr 19.

Direct visualization of alpha-synuclein oligomers reveals previously undetected pathology in Parkinson's disease brain.

Brain. 2015 Jun;138(Pt 6):1642-57. doi: 10.1093/brain/awv040. Epub 2015 Mar 1.

Prediagnostic presentations of Parkinson's disease in primary care: a case-control study.

Lancet Neurol. 2015 Jan;14(1):57-64. doi: 10.1016/S1474-4422(14)70287-X. Epub 2014 Nov 27.

Clinical correlations with Lewy body pathology in LRRK2-related Parkinson disease.

JAMA Neurol. 2015 Jan;72(1):100-5. doi: 10.1001/jamaneurol.2014.2704.

Stage-dependent nigral neuronal loss in incidental Lewy body and Parkinson's disease.

Mov Disord. 2014 Sep;29(10):1244-51. doi: 10.1002/mds.25952. Epub 2014 Jul 3.

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Parkinson disease in 2015: Evolving basic, pathological and clinical concepts in PD.

作者信息

Kalia Lorraine V, Lang Anthony E

机构信息

Krembil Research Institute and the Edmond J. Safra Program in Parkinson's Disease, Toronto Western Hospital, 399 Bathurst Street, Toronto, Ontario M5T 2S8, Canada.

出版信息

Nat Rev Neurol. 2016 Feb;12(2):65-6. doi: 10.1038/nrneurol.2015.249. Epub 2016 Jan 18.

DOI:10.1038/nrneurol.2015.249

PMID:26782330

Abstract

摘要

相似文献

Parkinson disease in 2015: Evolving basic, pathological and clinical concepts in PD.

Nat Rev Neurol. 2016 Feb;12(2):65-6. doi: 10.1038/nrneurol.2015.249. Epub 2016 Jan 18.

Parkinson disease: Peripheral α-synuclein deposits - prodromal markers for Parkinson disease?

Nat Rev Neurol. 2016 May;12(5):249. doi: 10.1038/nrneurol.2016.54. Epub 2016 Apr 15.

A critical evaluation of current staging of alpha-synuclein pathology in Lewy body disorders.

Biochim Biophys Acta. 2009 Jul;1792(7):730-40. doi: 10.1016/j.bbadis.2008.07.006. Epub 2008 Aug 5.

Alimentary, my dear Watson? The challenges of enteric α-synuclein as a Parkinson's disease biomarker.

Mov Disord. 2014 Apr;29(4):444-50. doi: 10.1002/mds.25789. Epub 2013 Dec 26.

[Disease-Modifying Therapy for Parkinson's Disease].

Brain Nerve. 2017 Feb;69(2):159-165. doi: 10.11477/mf.1416200656.

Direct evidence of Parkinson pathology spread from the gastrointestinal tract to the brain in rats.

Acta Neuropathol. 2014 Dec;128(6):805-20. doi: 10.1007/s00401-014-1343-6. Epub 2014 Oct 9.

Non-motor features of Parkinson disease.

Nat Rev Neurosci. 2017 Jul;18(7):435-450. doi: 10.1038/nrn.2017.62. Epub 2017 Jun 8.

Pure autonomic failure: a restricted Lewy body synucleinopathy or early Parkinson disease?

Neurology. 2010 Feb 16;74(7):536-7. doi: 10.1212/WNL.0b013e3181d26982.

Biomarkers in Prodromal Parkinson Disease: a Qualitative Review.

J Int Neuropsychol Soc. 2016 Nov;22(10):956-967. doi: 10.1017/S1355617716000503.

Diagnosis and treatment of Parkinson disease: molecules to medicine.

J Clin Invest. 2006 Jul;116(7):1744-54. doi: 10.1172/JCI29178.

引用本文的文献

Three Months of Partnered Dance Aerobic Exercise Can Reduce OFF-time and Enhance Quality of Life in Older Adults with Parkinson's Disease.

medRxiv. 2025 Jul 18:2025.07.17.25331727. doi: 10.1101/2025.07.17.25331727.

Autophagy in cancer and protein conformational disorders.

FEBS Lett. 2025 Aug;599(16):2250-2271. doi: 10.1002/1873-3468.70061. Epub 2025 May 8.

Deep Learning-Based Prediction of Freezing of Gait in Parkinson's Disease With the Ensemble Channel Selection Approach.

Brain Behav. 2025 Jan;15(1):e70206. doi: 10.1002/brb3.70206.

Therapeutic potential of mesenchymal stem cell-derived exosomes and miRNAs in neuronal regeneration and rejuvenation in neurological disorders: a mini review.

Front Cell Neurosci. 2024 Oct 4;18:1427525. doi: 10.3389/fncel.2024.1427525. eCollection 2024.

Digital biomarkers for precision diagnosis and monitoring in Parkinson's disease.

NPJ Digit Med. 2024 Aug 21;7(1):218. doi: 10.1038/s41746-024-01217-2.

Nuclear alpha-synuclein accelerates cell senescence and neurodegeneration.

Immun Ageing. 2024 Jul 12;21(1):47. doi: 10.1186/s12979-024-00429-0.

Excessive STAU1 condensate drives mTOR translation and autophagy dysfunction in neurodegeneration.

J Cell Biol. 2024 Aug 5;223(8). doi: 10.1083/jcb.202311127. Epub 2024 Jun 24.

Evaluation of the Transport and Binding of Dopamine-Loaded PLGA Nanoparticles for the Treatment of Parkinson's Disease Using In Vitro Model Systems.

Pharmaceutics. 2024 Apr 23;16(5):571. doi: 10.3390/pharmaceutics16050571.

The epidemiology of Parkinson's disease.

Lancet. 2024 Jan 20;403(10423):283-292. doi: 10.1016/S0140-6736(23)01419-8.

Association of accelerometer-measured physical activity intensity, sedentary time, and exercise time with incident Parkinson's disease.

NPJ Digit Med. 2023 Nov 28;6(1):224. doi: 10.1038/s41746-023-00969-7.

本文引用的文献

MDS research criteria for prodromal Parkinson's disease.

Mov Disord. 2015 Oct;30(12):1600-11. doi: 10.1002/mds.26431.

MDS clinical diagnostic criteria for Parkinson's disease.

Mov Disord. 2015 Oct;30(12):1591-601. doi: 10.1002/mds.26424.

Parkinson disease and incidental Lewy body disease: Just a question of time?

Neurology. 2015 Nov 10;85(19):1670-9. doi: 10.1212/WNL.0000000000002102. Epub 2015 Oct 14.

α-Synuclein strains cause distinct synucleinopathies after local and systemic administration.

Nature. 2015 Jun 18;522(7556):340-4. doi: 10.1038/nature14547. Epub 2015 Jun 10.

Vagotomy and subsequent risk of Parkinson's disease.

Ann Neurol. 2015 Oct;78(4):522-9. doi: 10.1002/ana.24448. Epub 2015 Jul 17.

Parkinson's disease.

Lancet. 2015 Aug 29;386(9996):896-912. doi: 10.1016/S0140-6736(14)61393-3. Epub 2015 Apr 19.

Direct visualization of alpha-synuclein oligomers reveals previously undetected pathology in Parkinson's disease brain.

Brain. 2015 Jun;138(Pt 6):1642-57. doi: 10.1093/brain/awv040. Epub 2015 Mar 1.

Prediagnostic presentations of Parkinson's disease in primary care: a case-control study.

Lancet Neurol. 2015 Jan;14(1):57-64. doi: 10.1016/S1474-4422(14)70287-X. Epub 2014 Nov 27.

Clinical correlations with Lewy body pathology in LRRK2-related Parkinson disease.

JAMA Neurol. 2015 Jan;72(1):100-5. doi: 10.1001/jamaneurol.2014.2704.

Stage-dependent nigral neuronal loss in incidental Lewy body and Parkinson's disease.

Mov Disord. 2014 Sep;29(10):1244-51. doi: 10.1002/mds.25952. Epub 2014 Jul 3.

Parkinson disease in 2015: Evolving basic, pathological and clinical concepts in PD.

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Parkinson disease in 2015: Evolving basic, pathological and clinical concepts in PD.

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