Liu Mengyi, Gan Xiaoqin, Ye Ziliang, Zhang Yuanyuan, He Panpan, Zhou Chun, Yang Sisi, Zhang Yanjun, Qin Xianhui
Division of Nephrology, Nanfang Hospital, Southern Medical University; National Clinical Research Center for Kidney Disease; State Key Laboratory of Organ Failure Research; Guangdong Provincial Institute of Nephrology; Guangdong Provincial Key Laboratory of Renal Failure Research, Guangzhou, 510515, China.
NPJ Digit Med. 2023 Nov 28;6(1):224. doi: 10.1038/s41746-023-00969-7.
Evidence regarding the association between physical activity and Parkinson's disease (PD) risk is generally limited due to the use of self-report questionnaires. We aimed to quantify the separate and combined effects of accelerometer-measured light physical activity (LPA), moderate-to-vigorous physical activity (MVPA), sedentary time and exercise timing with incident PD. 96,422 participants without prior PD and with usable accelerometer data were included from UK Biobank. Time spent in sedentary activity, LPA, MVPA, and exercise timing were estimated using machine learning models. The study outcome was incident PD. Over a median follow-up duration of 6.8 years, 313 participants developed PD. There was a L-shaped association for LPA and MVPA, and a reversed L-shaped association for sedentary time, with the risk of incident PD (all P for nonlinearity < 0.001). Similar trends were found across three time-windows (morning, midday-afternoon, and evening). Compared with those with both low LPA (<3.89 h/day) and low MVPA (<0.27 h/day), the adjusted HR (95% CI) of PD risk was 0.49 (0.36-0.66), 0.19 (0.36-0.66) and 0.13 (0.09-0.18), respectively, for participants with high MVPA only, high LPA only, and both high LPA and high MVPA. Moreover, participants with both low LPA and high sedentary time (≥9.41 h/day) (adjusted HR, 5.59; 95% CI: 4.10-7.61), and those with both low MVPA and high sedentary time (adjusted HR, 3.93; 95% CI: 2.82-5.49) had the highest risk of incident PD. In conclusion, regardless of exercise timing (morning, midday-afternoon, and evening), there was an inverse association for accelerometer-measured MVPA and LPA, and a positive association for sedentary time, with incident PD.
由于使用自我报告问卷，关于身体活动与帕金森病（PD）风险之间关联的证据通常有限。我们旨在量化通过加速度计测量的轻度身体活动（LPA）、中度至剧烈身体活动（MVPA）、久坐时间和运动时间对PD发病的单独和综合影响。来自英国生物银行的96422名无既往PD且有可用加速度计数据的参与者被纳入研究。使用机器学习模型估计久坐活动、LPA、MVPA和运动时间所花费的时间。研究结果是PD发病。在中位随访期6.8年期间，313名参与者患上了PD。LPA和MVPA呈L形关联，久坐时间呈倒L形关联，与PD发病风险相关（所有非线性P值均<0.001）。在三个时间窗口（早晨、中午至下午、晚上）均发现了类似趋势。与LPA低（<3.89小时/天）且MVPA低（<0.27小时/天）的参与者相比，仅MVPA高、仅LPA高以及LPA和MVPA均高的参与者发生PD风险的调整后HR（95%CI）分别为0.49（0.36 - 0.66）、0.19（0.36 - 0.66）和0.13（0.09 - 0.18）。此外，LPA低且久坐时间长（≥9.41小时/天）的参与者（调整后HR，5.59；95%CI：4.10 - 7.61）以及MVPA低且久坐时间长的参与者（调整后HR，3.93；95%CI：2.82 - 5.49）发生PD的风险最高。总之，无论运动时间（早晨、中午至下午、晚上）如何，通过加速度计测量的MVPA和LPA与PD发病呈负相关，久坐时间与PD发病呈正相关。
