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基于深度学习的帕金森病冻结步态预测与集成通道选择方法

Deep Learning-Based Prediction of Freezing of Gait in Parkinson's Disease With the Ensemble Channel Selection Approach.

作者信息

Abbasi Sara, Rezaee Khosro

机构信息

Department of Biomedical Engineering, Islamic Azad University of Mashhad, Mashhad, Iran.

Department of Biomedical Engineering, Meybod University, Meybod, Iran.

出版信息

Brain Behav. 2025 Jan;15(1):e70206. doi: 10.1002/brb3.70206.

DOI:10.1002/brb3.70206
PMID:39740772
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11688057/
Abstract

PURPOSE

A debilitating and poorly understood symptom of Parkinson's disease (PD) is freezing of gait (FoG), which increases the risk of falling. Clinical evaluations of FoG, relying on patients' subjective reports and manual examinations by specialists, are unreliable, and most detection methods are influenced by subject-specific factors.

METHOD

To address this, we developed a novel algorithm for detecting FoG events based on movement signals. To enhance efficiency, we propose a novel architecture integrating a bottleneck attention module into a standard bidirectional long short-term memory network (BiLSTM). This architecture, adaptable to a convolution bottleneck attention-BiLSTM (CBA-BiLSTM), classifies signals using data from ankle, leg, and trunk sensors.

FINDING

Given three movement directions from three locations, we reduce computational complexity in two phases: selecting optimal channels through ensemble learning followed by feature reduction using attention mapping. In FoG event detection tests, performance improved significantly compared to control groups and existing methods, achieving 99.88% accuracy with only two channels.

CONCLUSION

The reduced computational complexity enables real-time monitoring. Our approach demonstrates substantial improvements in classification results compared to traditional deep learning methods.

摘要

目的

帕金森病(PD)中一种使人衰弱且了解不足的症状是步态冻结(FoG),它会增加跌倒风险。基于患者主观报告和专家手动检查的FoG临床评估不可靠,并且大多数检测方法受个体因素影响。

方法

为解决此问题,我们开发了一种基于运动信号检测FoG事件的新算法。为提高效率,我们提出一种将瓶颈注意力模块集成到标准双向长短期记忆网络(BiLSTM)中的新架构。这种架构适用于卷积瓶颈注意力 - BiLSTM(CBA - BiLSTM),使用来自脚踝、腿部和躯干传感器的数据对信号进行分类。

发现

对于来自三个位置的三个运动方向,我们分两个阶段降低计算复杂度:通过集成学习选择最优通道,然后使用注意力映射进行特征约简。在FoG事件检测测试中,与对照组和现有方法相比性能显著提高,仅使用两个通道时准确率达到99.88%。

结论

降低的计算复杂度实现了实时监测。与传统深度学习方法相比,我们的方法在分类结果上有显著改进。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e30/11688057/a8aa22aba0ac/BRB3-15-e70206-g009.jpg
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Nat Med. 2024 Jan;30(1):177-185. doi: 10.1038/s41591-023-02731-8. Epub 2024 Jan 5.
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Comparison of sleep characteristics between Parkinson's disease with and without freezing of gait: A systematic review.比较伴和不伴冻结步态的帕金森病患者的睡眠特征:一项系统评价。
Sleep Med. 2024 Feb;114:24-41. doi: 10.1016/j.sleep.2023.11.021. Epub 2023 Dec 9.
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Freezing of gait in Parkinson's disease: Classification using computational intelligence.
帕金森病冻结步态:基于计算智能的分类。
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Classification of mild Parkinson's disease: data augmentation of time-series gait data obtained via inertial measurement units.基于惯性测量单元获取的时间序列步态数据的分类:轻度帕金森病的数据增强。
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BAFNet: Bottleneck Attention Based Fusion Network for Sleep Apnea Detection.BAFNet:基于瓶颈注意力融合网络的睡眠呼吸暂停检测。
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Multi-Modal Deep Learning Diagnosis of Parkinson's Disease-A Systematic Review.多模态深度学习在帕金森病诊断中的应用——系统评价
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