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高龄老年人的生存预后

Survival Prognosis in Very Old Adults.

作者信息

Thinggaard Mikael, McGue Matt, Jeune Bernard, Osler Merete, Vaupel James W, Christensen Kaare

机构信息

Danish Aging Research Center, University of Southern Denmark, Odense, Denmark.

Epidemiology, Biostatistics and Biodemography, University of Southern Denmark, Odense, Denmark.

出版信息

J Am Geriatr Soc. 2016 Jan;64(1):81-8. doi: 10.1111/jgs.13838.

Abstract

OBJECTIVES

To determine whether simple functional indicators are predictors of survival prognosis in very old adults.

DESIGN

In-person survey conducted over a 3-month period in 1998; assessment of survival over a 15-year follow-up period.

SETTING

Denmark.

PARTICIPANTS

All 3,600 Danes born in 1905 and living in Denmark in 1998, were invited to participate regardless of residence and health; 2,262 (63%) participated in the survey: 1,814 (80.2%) in person and 448 (19.8%) through a proxy.

MEASUREMENTS

Socioeconomic factors, medications and diseases, activities of daily living, physical performance, cognition, depression symptomatology, self-rated health, and all-cause mortality, evaluated as average remaining lifespan and chance of surviving to 100 years.

RESULTS

Men aged 92 to 93 had an overall 6.0% chance of surviving to 100 years, whereas the chance for women was 11.4%. Being able to rise without use of hands increased the chance for men to 11.2% (95% confidence interval (CI)=7.7-14.7) and for women to 22.0% (95% CI=18.9-25.1). When combining this with a Mini-Mental State Examination (MMSE) scores from 28 to 30, the chances were 21.7% (95% CI=11.5-31.9) for men and 34.2% (95% CI=24.8-43.5) for women.

CONCLUSION

Chair stand score combined with MMSE score is a quick and easy way to estimate overall chance of survival in very old adults, which is particularly relevant when treatment with potential side effects for nonacute diseases is considered.

摘要

目的

确定简单的功能指标是否为高龄成年人生存预后的预测因素。

设计

1998年在3个月内进行的面对面调查;对15年随访期内的生存情况进行评估。

地点

丹麦。

参与者

所有1905年出生且1998年居住在丹麦的3600名丹麦人,无论其居住地点和健康状况如何均被邀请参与;2262人(63%)参与了调查:1814人(80.2%)亲自参与,448人(19.8%)通过代理人参与。

测量指标

社会经济因素、药物和疾病、日常生活活动、身体机能、认知、抑郁症状、自评健康状况以及全因死亡率,评估指标为平均剩余寿命和活到100岁的几率。

结果

92至93岁的男性活到100岁的总体几率为6.0%,而女性为11.4%。能够不借助双手起身使男性活到100岁的几率增至11.2%(95%置信区间(CI)=7.7 - 14.7),女性增至22.0%(95% CI = 18.9 - 25.1)。将此与简易精神状态检查表(MMSE)得分28至30相结合时,男性活到100岁的几率为21.7%(95% CI = 11.5 - 31.9),女性为34.2%(95% CI = 24.8 - 43.5)。

结论

从椅子上起身得分与MMSE得分相结合是估计高龄成年人总体生存几率的一种快速简便方法,在考虑对非急性疾病使用可能有副作用的治疗方法时尤为重要。

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