治疗后胚胎性横纹肌肉瘤中的脂肪细胞样分化

Adipocyte-Like Differentiation in a Posttreatment Embryonal Rhabdomyosarcoma.

作者信息

Balitzer Dana, McCalmont Timothy H, Horvai Andrew E

机构信息

Department of Pathology, University of California, San Francisco, 505 Parnassus, M580, San Francisco, CA 94143, USA.

Departments of Pathology and Dermatology, University of California, San Francisco, 1701 Divisadero Street, Suite 280, San Francisco, CA 94115, USA.

出版信息

Case Rep Pathol. 2015;2015:406739. doi: 10.1155/2015/406739. Epub 2015 Dec 10.

DOI:10.1155/2015/406739

PMID:26783483

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4689918/

Abstract

We describe a 16-year-old boy with rhabdomyosarcoma, consistent with embryonal subtype, of the lower extremity who received systemic neoadjuvant chemotherapy and subsequent excision. Microscopic sections of the postchemotherapy excision demonstrated diffuse, prominent, and immature adipocyte-like differentiation, in addition to skeletal muscle differentiation. Adipocyte-like differentiation was confirmed by a combination of positive Oil Red O and adipophilin immunohistochemical staining. To our knowledge, this represents the first report of an unusual phenomenon of differentiation of a soft tissue rhabdomyosarcoma into adipocyte-like cells after chemotherapy.

摘要

我们描述了一名16岁患有横纹肌肉瘤的男孩，其下肢肿瘤符合胚胎型亚型，接受了全身新辅助化疗并随后进行了切除。化疗后切除标本的显微镜切片显示，除了骨骼肌分化外，还有弥漫性、显著且不成熟的脂肪细胞样分化。油红O和脂肪分化相关蛋白免疫组化染色均呈阳性，证实了脂肪细胞样分化。据我们所知，这是关于软组织横纹肌肉瘤在化疗后分化为脂肪细胞样细胞这一不寻常现象的首次报道。