Beretta-Piccoli C
Ospedale Italiano, Viganello.
Schweiz Med Wochenschr. 1989 Jul 22;119(29):1016-22.
In patients with chronic renal disease, hypertension represents an important risk factor for the development of cardiovascular complications. Moreover, it appears possible that the progression of chronic renal failure may be slowed by carefully adjusted antihypertensive therapy. Therefore, blood pressure needs to be monitored very closely in patients with kidney disease and, when indicated, antihypertensive treatment should be started as soon as blood pressure begins to rise. Antihypertensive treatment of patients with non-oliguric renal failure has usually been started with dietary salt restriction and diuretic monotherapy. Other drugs, such as beta-blockers, sympathicolytic and/or vasodilating agents have been added successively. The possibility of beginning antihypertensive therapy with alternative compounds (beta-blocker, calcium antagonists and converting enzyme inhibitors) in patients with non-oliguric renal failure is discussed.
在慢性肾病患者中,高血压是发生心血管并发症的一个重要危险因素。此外,通过精心调整的抗高血压治疗,似乎有可能减缓慢性肾衰竭的进展。因此,肾病患者的血压需要密切监测,并且在有指征时,一旦血压开始升高就应立即开始抗高血压治疗。非少尿型肾衰竭患者的抗高血压治疗通常始于饮食限盐和利尿剂单一疗法。其他药物,如β受体阻滞剂、抗交感神经药和/或血管扩张剂已相继添加。本文讨论了在非少尿型肾衰竭患者中开始使用替代化合物(β受体阻滞剂、钙拮抗剂和转换酶抑制剂)进行抗高血压治疗的可能性。