硒暴露与癌症风险：一项更新的荟萃分析和元回归分析
Selenium Exposure and Cancer Risk: an Updated Meta-analysis and Meta-regression.
作者信息
Cai Xianlei, Wang Chen, Yu Wanqi, Fan Wenjie, Wang Shan, Shen Ning, Wu Pengcheng, Li Xiuyang, Wang Fudi
机构信息
Institute of Environmental Medicine, Zhejiang University, P.R.China.
Ningbo Medical Treatment Center Lihuili Hospital, P.R.China.
出版信息
Sci Rep. 2016 Jan 20;6:19213. doi: 10.1038/srep19213.
The objective of this study was to investigate the associations between selenium exposure and cancer risk. We identified 69 studies and applied meta-analysis, meta-regression and dose-response analysis to obtain available evidence. The results indicated that high selenium exposure had a protective effect on cancer risk (pooled OR = 0.78; 95%CI: 0.73-0.83). The results of linear and nonlinear dose-response analysis indicated that high serum/plasma selenium and toenail selenium had the efficacy on cancer prevention. However, we did not find a protective efficacy of selenium supplement. High selenium exposure may have different effects on specific types of cancer. It decreased the risk of breast cancer, lung cancer, esophageal cancer, gastric cancer, and prostate cancer, but it was not associated with colorectal cancer, bladder cancer, and skin cancer.
本研究的目的是调查硒暴露与癌症风险之间的关联。我们识别出69项研究，并应用荟萃分析、荟萃回归和剂量反应分析来获取现有证据。结果表明，高硒暴露对癌症风险具有保护作用（合并比值比=0.78；95%置信区间：0.73-0.83）。线性和非线性剂量反应分析结果表明，高血清/血浆硒和 toenail 硒具有预防癌症的功效。然而，我们未发现补充硒的保护功效。高硒暴露可能对特定类型的癌症有不同影响。它降低了乳腺癌、肺癌、食管癌、胃癌和前列腺癌的风险，但与结直肠癌、膀胱癌和皮肤癌无关。 （注：原文中“toenail selenium”可能有误，推测可能是“toenail selenium level”之类更准确的表述）
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