Kallio T, Alanen A, Kormano M
Department of Diagnostic Radiology, Turku University Central Hospital, Finland.
Ultrasound Med Biol. 1989;15(6):555-9. doi: 10.1016/0301-5629(89)90188-9.
Blood echogenicity was measured in four patient groups with circulatory disturbances (myocardial infarction, stroke, claudication, and deep venous thrombosis) at hospital admission and one week later. The recording was done by an A-mode ultrasonic method at three shear rates down to 4.1 s-1. The rheological effects of adding an anti-aggregatory drug, naftidrofuryl, was tested in vitro at concentrations ranging from 10(-8)-10(-6) M. Echogenicity was lowest in blood from healthy volunteers and significantly greater in blood from patients with claudication. The in vitro addition of naftidrofuryl significantly lowered the echogenicity of blood samples taken from patients with venous thrombosis in the lower extremities. The authors suggest that increased blood echogenicity, which can be pharmacologically manipulated, may be a nonspecific indicator of disease.
在入院时及一周后，对四组患有循环系统障碍（心肌梗死、中风、跛行和深静脉血栓形成）的患者的血液回声性进行了测量。采用A模式超声方法在低至4.1 s-1的三种剪切速率下进行记录。在体外测试了添加抗聚集药物萘呋胺酯（浓度范围为10(-8)-10(-6) M）的流变学效应。健康志愿者血液的回声性最低，而跛行患者血液的回声性显著更高。体外添加萘呋胺酯可显著降低从下肢静脉血栓形成患者采集的血样的回声性。作者认为，血液回声性增加可通过药理学手段进行调控，可能是疾病的一种非特异性指标。
