Kim J S, Kim S J, Shin K J, Hwang P H, Cho S C
Yonsei Med J. 1989;30(2):158-63. doi: 10.3349/ymj.1989.30.2.158.
We evaluated tetanus specific IgG, IgM, IgG subclasses after DPT vaccination in infants and children. Tetanus toxoid specific IgG, IgM IgG subclasses were measured to characterize the isotope profile of antibody against tetanus toxoid. The values of the tetanus specific IgG in the positive group were significantly increased compared to those of the control group, and were significantly increased after two inoculation. Tetanus specific IgG was very low in adults and neonates. In our tetanus specific IgG subclasses study, forty-five of 56 cases (80%) showed predominantly IgG1 antibody responses to tetanus toxoid, while twenty-five of 56 cases (45%) showed IgG4 responses. Both IgG1 and IgG4 responses were demonstrated in 17 cases (30%). So we suggest that IgG was mainly involved in humoral immune response after DPT vaccination, and IgG1 may play an important role among IgG subclasses. IgG4, alone or together with IgG1, can also play a role in immune response to tetanus toxoid.
我们评估了婴幼儿和儿童接种百白破疫苗（DPT）后破伤风特异性IgG、IgM、IgG亚类的情况。检测破伤风类毒素特异性IgG、IgM、IgG亚类，以表征抗破伤风类毒素抗体的同种型谱。阳性组破伤风特异性IgG值与对照组相比显著升高，且两次接种后显著增加。成人和新生儿的破伤风特异性IgG水平很低。在我们关于破伤风特异性IgG亚类的研究中，56例中有45例（80%）对破伤风类毒素主要表现为IgG1抗体反应，而56例中有25例（45%）表现为IgG4反应。17例（30%）同时表现出IgG1和IgG4反应。因此我们认为，接种DPT疫苗后IgG主要参与体液免疫反应，且IgG1可能在IgG亚类中起重要作用。IgG4单独或与IgG1一起，也可在抗破伤风类毒素的免疫反应中发挥作用。
