Tomita H, Ogawa M, Kamijo T, Mori O, Ishikawa E, Mohri Z, Murakami Y
Department of Pediatrics, School of Medicine, Nagoya University, Japan.
Acta Endocrinol (Copenh). 1989 Oct;121(4):513-9. doi: 10.1530/acta.0.1210513.
GH values were determined by a highly sensitive sandwich enzyme immunoassay in the 1st morning and/or 24-h accumulated urine samples in 94 children (short stature 70, including 14 with complete GH deficiency, 9 with partial GH deficiency, and 47 with GH-normal short stature; Turner's syndrome, 10, and simple obesity, 14). GH values were also determined in the 2nd to 4th urine samples taken on the same day together with the 1st morning urine in 5 of them. GH values in the 1st morning urine correlated significantly with those of the 24-h urine and with serum peak and mean GH values during nocturnal sleep as a physiological GH secretion test. The 2nd to 4th urines had lower GH concentrations than the 1st morning urine. The GH value of the 1st morning urine in complete GH deficiency was significantly lower than those in GH-normal short stature, partial GH deficiency and Turner's syndrome. However, no significant difference was detected in urinary GH values between complete GH deficiency and simple obesity. We conclude that 1st morning urinary GH estimation may be useful for differentiation of complete GH deficiency from other causes of short stature, but may be difficult for the distinction between complete GH-deficiency and obesity with normal GH secretory ability.
采用高灵敏度夹心酶免疫分析法对94例儿童（70例身材矮小，其中14例完全性生长激素缺乏，9例部分性生长激素缺乏，47例生长激素正常的身材矮小；10例特纳综合征，14例单纯性肥胖）第1天晨尿和/或24小时累积尿样中的生长激素值进行测定。对其中5例还测定了同一天采集的第2至第4次尿样以及第1天晨尿中的生长激素值。作为生理性生长激素分泌试验，第1天晨尿中的生长激素值与24小时尿样中的生长激素值以及夜间睡眠期间的血清生长激素峰值和平均生长激素值显著相关。第2至第4次尿样的生长激素浓度低于第1天晨尿。完全性生长激素缺乏患儿第1天晨尿中的生长激素值显著低于生长激素正常的身材矮小、部分性生长激素缺乏和特纳综合征患儿。然而，完全性生长激素缺乏与单纯性肥胖患儿的尿生长激素值之间未检测到显著差异。我们得出结论，第1天晨尿生长激素测定可能有助于将完全性生长激素缺乏与其他身材矮小原因相鉴别，但可能难以区分完全性生长激素缺乏与生长激素分泌能力正常的肥胖。
