Pan Hongming, Chen Liuxi, Xu Yinghua, Han Weidong, Lou Fang, Fei Weiqiang, Liu Shuiping, Jing Zhao, Sui Xinbing
Department of Medical Oncology, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, China.
Biomedical Research Center and Key Laboratory of Biotherapy of Zhejiang Province, Hangzhou, China.
Oncotarget. 2016 Apr 19;7(16):21235-46. doi: 10.18632/oncotarget.6908.
Autophagy is an evolutionarily conserved catabolic process by which cellular components are sequestered into a double-membrane vesicle and delivered to the lysosome for terminal degradation and recycling. Accumulating evidence suggests that autophagy plays a critical role in cell survival, senescence and homeostasis, and its dysregulation is associated with a variety of diseases including cancer, cardiovascular disease, neurodegeneration. Recent studies show that autophagy is also an important regulator of cell immune response. However, the mechanism by which autophagy regulates tumor immune responses remains elusive. In this review, we will describe the role of autophagy in immune regulation and summarize the possible molecular mechanisms that are currently well documented in the ability of autophagy to control cell immune response. In addition, the scientific and clinical hurdles regarding the potential role of autophagy in cancer immunotherapy will be discussed.
自噬是一种进化上保守的分解代谢过程，通过该过程细胞成分被隔离到双膜囊泡中，并被输送到溶酶体进行最终降解和再循环。越来越多的证据表明，自噬在细胞存活、衰老和体内平衡中起关键作用，其失调与包括癌症、心血管疾病、神经退行性变在内的多种疾病相关。最近的研究表明，自噬也是细胞免疫反应的重要调节因子。然而，自噬调节肿瘤免疫反应的机制仍不清楚。在这篇综述中，我们将描述自噬在免疫调节中的作用，并总结目前有充分文献记载的自噬控制细胞免疫反应能力的可能分子机制。此外，还将讨论关于自噬在癌症免疫治疗中潜在作用的科学和临床障碍。
