School of Life Sciences, University of Science and Technology of China, Hefei, Anhui, 230027, PR China; Guangzhou First People's Hospital, School of Medicine and Institutes for Life Sciences, South China University of Technology, Guangzhou, Guangdong, 510006, PR China.
Guangzhou First People's Hospital, School of Medicine and Institutes for Life Sciences, South China University of Technology, Guangzhou, Guangdong, 510006, PR China.
Cancer Lett. 2020 Apr 10;475:34-42. doi: 10.1016/j.canlet.2020.01.034. Epub 2020 Jan 31.
Autophagy plays a critical role in intracellular metabolism and maintaining cellular homeostasis. Certain tumor cells present a higher basal autophagy rate and autophagy inhibition can lead to impaired metabolic dysfunction in autophagy-dependent tumor cells. Autophagy status in immune cells dictates their fate and response to antigen; however, autophagy in immune cells may be beneficial or detrimental depending on the developmental stage of the cell and more specifically its degree of differentiation. Autophagy-deficient hosts present variations in many metabolites, proteins and enzymes that may have tumor-promoting or -inhibiting effects. The centrality of autophagy in the metabolism of some cancers and immune cells poses as a critical target whose mechanisms must be further unraveled to optimize patient response and prevent tumor recurrence.
自噬在细胞内代谢和维持细胞内稳态中起着关键作用。某些肿瘤细胞表现出更高的基础自噬率，而自噬抑制会导致自噬依赖性肿瘤细胞代谢功能障碍。免疫细胞中的自噬状态决定了它们对抗原的命运和反应；然而，免疫细胞中的自噬可能是有益的，也可能是有害的，这取决于细胞的发育阶段，更具体地说，取决于其分化程度。自噬缺陷宿主的许多代谢物、蛋白质和酶都存在差异，这些差异可能具有促进或抑制肿瘤的作用。自噬在某些癌症和免疫细胞的代谢中的核心作用是一个关键靶点，必须进一步阐明其机制，以优化患者的反应并防止肿瘤复发。
