Elkard I, Zaghba N, Benjelloun H, Bakhatar A, Yassine N
Service des maladies respiratoires, CHU Ibn Rochd, Casablanca, Maroc.
Service des maladies respiratoires, CHU Ibn Rochd, Casablanca, Maroc.
Rev Pneumol Clin. 2016 May;72(3):179-83. doi: 10.1016/j.pneumo.2015.10.003. Epub 2016 Jan 12.
Tuberculosis is a serious and common complication of silicosis. The aim of this study is to describe the epidemiological, clinical, radiological and progressive aspects of this pathological entity.
The study concerns 23 cases of silicotuberculosis which were collected at the service of respiratory diseases at CHU Ibn Rochd of Casablanca, Morocco during 12years (2003-2015).
All patients were men. They were 7 diggers, 5 rock crushers, 7 miners and 4 masons. The mean duration of silica exposure was 11years. The symptomatology was dominated by dyspnea and persistent bronchial syndrome. Imagery showed tumor-like opacities in all cases, associated with mediastinal calcified lymphadenopathy in 9 cases, with micronodules in 8 cases and an excavated opacity in 2 cases. The diagnosis of tuberculosis was confirmed by isolation of the Koch's bacillus in sputum in 13% of cases in the bronchial aspirate in 52% and culture in sputum post-bronchoscopy in 13%. The bronchial biopsies confirmed the diagnosis in 2 cases. Tuberculosis had complicated silicosis 9years on average after the cessation of exposure to silica in 65% of cases. The antituberculous treatment was started in all patients with good clinical outcome in 22 cases. We had deplored a case of death by acute respiratory failure.
Silicosis increases the risk of tuberculosis, hence the importance of TB screening in all patients with silicosis.
肺结核是矽肺一种严重且常见的并发症。本研究旨在描述这一病理实体的流行病学、临床、放射学及进展方面的情况。
本研究涉及23例矽肺结核病例,于12年期间(2003 - 2015年)在摩洛哥卡萨布兰卡伊本·罗什德大学医院呼吸科收集。
所有患者均为男性。其中7名挖掘工,5名碎石工,7名矿工和4名泥瓦匠。二氧化硅暴露的平均时长为11年。症状以呼吸困难和持续性支气管综合征为主。影像学检查显示所有病例均有肿瘤样混浊,9例伴有纵隔钙化淋巴结病,8例伴有微小结节,2例有空洞性混浊。13%的病例通过痰液中分离出结核杆菌确诊肺结核,52%通过支气管吸出物确诊,13%通过支气管镜检查后痰液培养确诊。2例经支气管活检确诊。65%的病例中,肺结核在停止接触二氧化硅后平均9年并发矽肺。所有患者均开始抗结核治疗,22例临床预后良好。我们曾痛惜1例因急性呼吸衰竭死亡的病例。
矽肺增加了患肺结核的风险,因此对所有矽肺患者进行肺结核筛查很重要。