Bangerter Patrick Daniel, Sidler Xaver, Perreten Vincent, Overesch Gudrun
Institute of Veterinary Bacteriology, Vetsuisse Faculty, University of Bern, Länggassstrasse 122, CH-3012 Bern, Switzerland.
Department of Farm Animals, Division of Swine Medicine, Vetsuisse Faculty, University of Zurich, Winterthurerstrasse 260, CH-8057 Zurich, Switzerland.
Vet Microbiol. 2016 Feb 1;183:125-34. doi: 10.1016/j.vetmic.2015.12.007. Epub 2015 Dec 17.
Knowledge about the dynamics of methicillin-resistant Staphylococcus aureus (MRSA) in pigs lacks detail at the level of individual animal. The aim of our study was therefore to determine the colonisation status of MRSA in individual pigs from birth to slaughter in order to gain a better understanding of substantial factors involved in transmission. Two farrow-to-finish and two grow-to-finish herds were included in the study. A total of 1728 nasal swabs from 390 pigs and 592 environmental wipes were collected at 11 different time points. Intermittent colonisation throughout the entire production cycle was conspicuous in the tracking of MRSA in individual pigs. Almost all pigs from a MRSA-positive herd changed MRSA status several times, which implies that pigs are transiently rather than permanently colonised. We highly recommend the definition of MRSA status at herd level rather that at the level of the individual pig when considering prevention measures against MRSA. Therefore, to avoid the further spread of MRSA in countries with moderate prevalence, such as in Switzerland, defining farms as MRSA positive or MRSA negative and allowing the trade of pigs only within herds of the same status seems feasible. This will also be important for combating the further dissemination of livestock-associated (LA)-MRSA into healthcare facilities and the community via humans who have close contact with animals.
关于猪体内耐甲氧西林金黄色葡萄球菌（MRSA）动态变化的知识在个体动物层面缺乏详细信息。因此，我们研究的目的是确定从出生到屠宰的个体猪中MRSA的定植状况，以便更好地了解传播过程中的重要因素。该研究纳入了两个自繁自养和两个育肥猪群。在11个不同时间点共采集了来自390头猪的1728份鼻拭子和592份环境擦拭样本。在对个体猪的MRSA追踪中，整个生产周期内的间歇性定植现象很明显。几乎所有来自MRSA阳性猪群的猪都多次改变了MRSA状态，这意味着猪是短暂而非永久定植。在考虑针对MRSA的预防措施时，我们强烈建议在猪群层面而非个体猪层面定义MRSA状态。因此，为避免MRSA在瑞士等中等流行率国家进一步传播，将农场定义为MRSA阳性或阴性，并仅允许相同状态猪群内的猪进行交易似乎是可行的。这对于通过与动物密切接触的人来对抗家畜相关（LA）-MRSA向医疗机构和社区的进一步传播也很重要。
