Laboratório de Flavivirus, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz /FIOCRUZ, Rio de Janeiro- RJ, Brazil.
Laboratório de Biotecnologia e Fisiologia de Infecções Virais, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz /FIOCRUZ, Rio de Janeiro- RJ, Brazil.
J Med Virol. 2016 Aug;88(8):1448-52. doi: 10.1002/jmv.24479. Epub 2016 Feb 2.
In Brazil, dengue is a public health problem with the occurrence of explosive epidemics. This study reports maternal and fetal deaths due to dengue and which tissues of placenta and umbilical cord were analyzed by molecular methods and immunohistochemistry. The dengue NS3 and NS1 detection revealed the viral presence in different cells from placenta and umbilical cord. In the latter, DENV-2 was detected at a viral titer of 1,02 × 10(4) amounts of viral RNA. It was shown that the DENV markers analyzed here may be an alternative approach for dengue fatal cases investigation, especially involving maternal and fetal death. J. Med. Virol. 88:1448-1452, 2016. © 2016 Wiley Periodicals, Inc.
在巴西，登革热是一个具有爆发性流行特点的公共卫生问题。本研究报告了因登革热导致的母婴死亡病例，以及应用分子方法和免疫组织化学对胎盘和脐带组织进行的分析。登革热 NS3 和 NS1 的检测显示病毒存在于胎盘和脐带的不同细胞中。在后者中，检测到登革热病毒 2 型（DENV-2）的病毒滴度为 1.02×10(4)数量的病毒 RNA。结果表明，这里分析的登革热病毒标志物可能是登革热致死病例调查的一种替代方法，特别是在涉及母婴死亡的情况下。医学病毒学杂志 88:1448-1452, 2016。© 2016 年 Wiley 期刊出版公司
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