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A trilogy of glucocorticoid receptor actions.

作者信息

Tan Chek Kun, Wahli Walter

机构信息

Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore 637553;

Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore 637553; Center for Integrative Genomics, University of Lausanne, CH-1015 Lausanne, Switzerland; Institut National de la Recherche Agronomique, Université de Toulouse, UMR1331, ToxAlim, Research Center in Food Toxicology, 31027 Toulouse, France

出版信息

Proc Natl Acad Sci U S A. 2016 Feb 2;113(5):1115-7. doi: 10.1073/pnas.1524215113. Epub 2016 Jan 20.

Abstract
摘要

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Glucocorticoid-induced tethered transrepression requires SUMOylation of GR and formation of a SUMO-SMRT/NCoR1-HDAC3 repressing complex.
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2
GR SUMOylation and formation of an SUMO-SMRT/NCoR1-HDAC3 repressing complex is mandatory for GC-induced IR nGRE-mediated transrepression.
Proc Natl Acad Sci U S A. 2016 Feb 2;113(5):E626-34. doi: 10.1073/pnas.1522821113. Epub 2015 Dec 28.
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