Laboratory of Genetics, Department of Biotechnology, School of Applied Biology and Biotechnology, Agricultural University of Athens, 11855 Athens, Greece.
Laboratory of Clinical Virology, School of Medicine, University of Crete, 71003 Heraklion, Greece.
Int J Mol Med. 2022 Dec;50(6). doi: 10.3892/ijmm.2022.5203. Epub 2022 Nov 11.
The synthesis and release of glucocorticoids in living organisms are related to their response to unfavorable stressful conditions in order to maintain homeostatic functions and survive. One such hormone in humans is cortisol, which is produced by the hypothalamic‑pituitary‑adrenal cortex axis and binds with the glucocorticoid receptor (GR) following its secretion. GR controls a number of distinct gene networks. Non‑coding RNAs (ncRNAs), such as microRNAs (miRNAs) and long non‑coding RNAs (lncRNAs), regulate the expression and function of GR, having a considerable impact on various biological processes and treatment approaches for numerous disorders. In the present review, the GR pathways and signaling as part of the stress response system are discussed. A detailed report on the role of miRNAs and lncRNAs in glucocorticoid signaling is also presented.
生物体中糖皮质激素的合成和释放与其对不利应激条件的反应有关，以维持内稳态功能和生存。在人类中，这种激素是皮质醇，它由下丘脑-垂体-肾上腺皮质轴产生，并在分泌后与糖皮质激素受体 (GR) 结合。GR 控制着许多不同的基因网络。非编码 RNA（ncRNA），如 microRNAs（miRNAs）和长非编码 RNA（lncRNAs），调节 GR 的表达和功能，对各种生物学过程和许多疾病的治疗方法有重大影响。在本综述中，讨论了作为应激反应系统一部分的 GR 途径和信号转导。还详细报告了 miRNAs 和 lncRNAs 在糖皮质激素信号转导中的作用。
