Department of Pediatrics, University of Pittsburgh School of Medicine Pittsburgh, PA, USA.
Department of Pediatrics, University of Pittsburgh School of MedicinePittsburgh, PA, USA; Department of Pediatrics, Richard King Mellon Foundation Institute for Pediatric Research, University of Pittsburgh School of MedicinePittsburgh, PA, USA.
Front Cell Dev Biol. 2016 Jan 13;3:85. doi: 10.3389/fcell.2015.00085. eCollection 2015.
Interleukin (IL)-22 is a member of the IL-10 family of cytokines that has been extensively studied since its discovery in 2000. This review article aims to describe the cellular sources and signaling pathways of this cytokine as well as the functions of IL-22 in the intestine. In addition, this article describes the roles of IL-22 in the pathogenesis of several gastrointestinal diseases, including inhibition of inflammation and barrier defense against pathogens within the intestine. Since many of the functions of IL-22 in the intestine are incompletely understood, this review is meant to assess our current understanding of the roles of IL-22 and provide new opportunities for inquiry to improve human intestinal health and disease.
白细胞介素 (IL)-22 是细胞因子 IL-10 家族的成员，自 2000 年发现以来，已得到广泛研究。本文旨在描述这种细胞因子的细胞来源和信号通路，以及 IL-22 在肠道中的功能。此外，本文还描述了 IL-22 在几种胃肠道疾病发病机制中的作用，包括抑制炎症和抵抗肠道内病原体的屏障防御。由于 IL-22 在肠道中的许多功能尚未完全了解，因此本文旨在评估我们目前对 IL-22 作用的理解，并为改善人类肠道健康和疾病提供新的研究机会。
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