微小 RNA 在食管鳞状细胞癌中的作用。
The role of microRNA in esophageal squamous cell carcinoma.
机构信息
Department of Gastroenterological Surgery, Graduate School of Medical Science, Kumamoto University, 1-1-1 Honjo, Kumamoto, 860-8556, Japan.
Department of Gastroenterological Surgery, Cancer Institute Hospital, Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-ku, Tokyo, 135-8550, Japan.
出版信息
J Gastroenterol. 2016 Jun;51(6):520-30. doi: 10.1007/s00535-016-1161-9. Epub 2016 Jan 21.
MicroRNAs (miRNA) are 22-nucleotide non-coding RNAs that post-transcriptionally regulate gene expression by base pairing to partially complementary sequences in the 3'-untranslated region of their target messenger RNA. Altered miRNA expression also changes the expression of oncogenes and tumor suppressors, affecting the proliferation, apoptosis, motility and invasibility of gastrointestinal cancer cells, including the cells of esophageal squamous cell carcinoma (ESCC). It has been suggested that various miRNA expression profiles may provide useful biomarkers and therapeutic targets, but to date few studies have been published on the role of miRNA in ESCC. In this review we summarize the identification and characterization of miRNAs involved in ESCC and discuss their potential as biomarkers and therapeutic targets.
微小 RNA（miRNA）是 22 个核苷酸的非编码 RNA，通过与靶信使 RNA 的 3'-非翻译区部分互补序列碱基配对，在后转录水平上调节基因表达。miRNA 表达的改变也会改变癌基因和肿瘤抑制基因的表达，影响胃肠道癌细胞的增殖、凋亡、运动性和侵袭性，包括食管鳞状细胞癌（ESCC）细胞。已经有研究表明，各种 miRNA 表达谱可能提供有用的生物标志物和治疗靶点，但迄今为止，关于 miRNA 在 ESCC 中的作用的研究很少。在这篇综述中，我们总结了参与 ESCC 的 miRNA 的鉴定和特征，并讨论了它们作为生物标志物和治疗靶点的潜力。
Zotero 插件