在有限种群中，突变和选择压力下遗传变异性的维持。
Maintenance of genetic variability under mutation and selection pressures in a finite population.
作者信息
Li W H
出版信息
Proc Natl Acad Sci U S A. 1977 Jun;74(6):2509-13. doi: 10.1073/pnas.74.6.2509.
Abstract
Formulas are developed for the distribution of allele frequencies and the mean and variance of heterozygosity under mutation and selection pressures. In large populations, even slight selection drastically changes the shape of the distribution of allele frequencies and reduces heterozygosity. On the other hand, the number of rare alleles in a sample is much less affected by selection. Under genic selection, heterozygosity may decrease with increasing population size. As a test statistic, the variance of heterozygosity can be used to detect the presence of selection, though it is not efficient when selection is very slight.
摘要
推导了在突变和选择压力下等位基因频率分布以及杂合度均值和方差的公式。在大种群中，即使是轻微的选择也会极大地改变等位基因频率分布的形状并降低杂合度。另一方面，样本中稀有等位基因的数量受选择的影响要小得多。在基因选择下，杂合度可能会随着种群规模的增加而降低。作为一种检验统计量，杂合度方差可用于检测选择的存在，不过当选择非常轻微时它并不高效。
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本文引用的文献
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