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本文引用的文献

1
THE NUMBER OF ALLELES THAT CAN BE MAINTAINED IN A FINITE POPULATION.有限种群中能够维持的等位基因数量。
Genetics. 1964 Apr;49(4):725-38. doi: 10.1093/genetics/49.4.725.
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The sampling theory of selectively neutral alleles.选择性中性等位基因的抽样理论
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3
Variability in the amount of heterozygosity maintained by neutral mutations.由中性突变维持的杂合性数量的变异性。
Theor Popul Biol. 1976 Apr;9(2):188-201. doi: 10.1016/0040-5809(76)90044-7.
4
Drift variances of heterozygosity and genetic distance in transient states.过渡状态下杂合度和遗传距离的漂移方差。
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5
Role of very slightly deleterious mutations in molecular evolution and polymorphism.轻度有害突变在分子进化和多态性中的作用。
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在有限种群中，突变和选择压力下遗传变异性的维持。

Maintenance of genetic variability under mutation and selection pressures in a finite population.

作者信息

Li W H

出版信息

Proc Natl Acad Sci U S A. 1977 Jun;74(6):2509-13. doi: 10.1073/pnas.74.6.2509.

DOI:10.1073/pnas.74.6.2509
PMID:267944
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC432202/
Abstract

Formulas are developed for the distribution of allele frequencies and the mean and variance of heterozygosity under mutation and selection pressures. In large populations, even slight selection drastically changes the shape of the distribution of allele frequencies and reduces heterozygosity. On the other hand, the number of rare alleles in a sample is much less affected by selection. Under genic selection, heterozygosity may decrease with increasing population size. As a test statistic, the variance of heterozygosity can be used to detect the presence of selection, though it is not efficient when selection is very slight.

摘要

推导了在突变和选择压力下等位基因频率分布以及杂合度均值和方差的公式。在大种群中，即使是轻微的选择也会极大地改变等位基因频率分布的形状并降低杂合度。另一方面，样本中稀有等位基因的数量受选择的影响要小得多。在基因选择下，杂合度可能会随着种群规模的增加而降低。作为一种检验统计量，杂合度方差可用于检测选择的存在，不过当选择非常轻微时它并不高效。