关于回文序列在免疫球蛋白基因中的位置
On the location of palindromes in immunoglobulin genes.
作者信息
Wuilmart C, Urbain J, Givol D
出版信息
Proc Natl Acad Sci U S A. 1977 Jun;74(6):2526-30. doi: 10.1073/pnas.74.6.2526.
Abstract
We present a statistical method for detection of palindromes in mRNA or DNA, starting from the protein sequence. Analysis of immunoglobulin genes by this method demonstrates that palindromic sequences are not randomly distributed. They are located at each side of the hypervariable regions in the variable (V) genes, whereas no such regular design is observed in the constant (C) genes. In addition, palindromic sequences overlap the V-C junction in all immunoglobulin classes and significant palindromes are present near residue 216 of the heavy chain, which is the end of deletions in many heavy chain diseases. The relevance of these palindromes to gene translocation and generation of diversity in antibodies is discussed.
摘要
我们提出了一种从蛋白质序列出发检测mRNA或DNA中回文序列的统计方法。用该方法对免疫球蛋白基因进行分析表明，回文序列并非随机分布。它们位于可变（V）基因高变区的两侧，而在恒定（C）基因中未观察到这种规则模式。此外，回文序列在所有免疫球蛋白类别中都与V-C连接区重叠，并且在重链的第216位残基附近存在显著的回文序列，该残基是许多重链疾病中缺失的末端。本文讨论了这些回文序列与基因易位及抗体多样性产生的相关性。
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