小鼠免疫球蛋白重链由多个种系可变区基因编码。
Mouse immunoglobulin heavy chains are coded by multiple germ line variable region genes.
作者信息
Barstad P, Farnsworth V, Weigert M, Cohn M, Hood L
出版信息
Proc Natl Acad Sci U S A. 1974 Oct;71(10):4096-100. doi: 10.1073/pnas.71.10.4096.
Abstract
The N-terminal 20 residues of 13 heavy immunoglobulin chains from myeloma protein of the BALB/c mouse are compared with the same residues of 15 other heavy chains described in the literature. Sixteen of 28 sequences are different from one another. These proteins fall into four major sets, with 18 of the proteins in the largest set being further divisible into at least five subsets. This pattern of diversity suggests there are at least eight germ line genes coding for the variable regions of mouse heavy chain. Many of the immunoglobulins from which these heavy chains are derived exhibit binding activity for various haptens. The differing hapten specificities are closely correlated with distinct primary amino-acid sequences.
摘要
将来自BALB/c小鼠骨髓瘤蛋白的13条重免疫球蛋白链的N端20个残基与文献中描述的其他15条重链的相同残基进行了比较。28个序列中的16个彼此不同。这些蛋白质分为四大组，最大一组中的18种蛋白质可进一步细分为至少五个亚组。这种多样性模式表明，至少有八个种系基因编码小鼠重链的可变区。这些重链所源自的许多免疫球蛋白对各种半抗原有结合活性。不同的半抗原特异性与不同的一级氨基酸序列密切相关。
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Proc Natl Acad Sci U S A. 1974 Oct;71(10):4096-100. doi: 10.1073/pnas.71.10.4096.
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引用本文的文献
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本文引用的文献
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An analysis of the sequences of the variable regions of Bence Jones proteins and myeloma light chains and their implications for antibody complementarity.本斯·琼斯蛋白和骨髓瘤轻链可变区序列分析及其对抗体互补性的影响。
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Variability in the lambda light chain sequences of mouse antibody.小鼠抗体λ轻链序列的变异性
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Antibody structure and molecular immunology.抗体结构与分子免疫学
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Quantitative procedures for use with the Edman-Begg sequenator. Partial sequences of two unusual immunoglobulin light chains, Rzf and Sac.用于埃德曼-贝格蛋白质测序仪的定量方法。两种异常免疫球蛋白轻链Rzf和Sac的部分序列。
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A new mouse immunoglobulin: IgG3.一种新的小鼠免疫球蛋白：IgG3。
J Exp Med. 1971 Feb 1;133(2):289-304. doi: 10.1084/jem.133.2.289.
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Eur J Biochem. 1972 Jan 21;24(3):446-55. doi: 10.1111/j.1432-1033.1972.tb19705.x.
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