免疫球蛋白基因可变区和恒定区的偏好密码子使用情况彼此截然不同。
The preferential codon usages in variable and constant regions of immunoglobulin genes are quite distinct from each other.
作者信息
Miyata T, Hayashida H, Yasunaga T, Hasegawa M
出版信息
Nucleic Acids Res. 1979 Dec 20;7(8):2431-8. doi: 10.1093/nar/7.8.2431.
Abstract
The pattern of codon utilization in the variable and constant regions of immunoglobulin genes are compared. It is shown that, in these regions, codon utilizations are quite distinct from one another: For most degenerate codons, there is a selective bias that prefers C and/or G ending codons to U and/or A ending codons in the constant region compared with the bias in the variable region. This would strongly suggest that, in immunoglobulin genes, the bias in code word usage is determined by other factors than those concerning with the translational mechanism such as tRNA availability and codon-anticodon interaction. A possibility is also suggested that this differance of code word usage between them is due to the existence of secondary structure in the constant region but not in the variable region.
摘要
对免疫球蛋白基因可变区和恒定区的密码子使用模式进行了比较。结果表明，在这些区域中，密码子使用情况彼此截然不同：对于大多数简并密码子，与可变区的偏好相比，恒定区存在一种选择性偏好，即更倾向于以C和/或G结尾的密码子而非以U和/或A结尾的密码子。这有力地表明，在免疫球蛋白基因中，密码子使用的偏好是由与翻译机制（如tRNA可用性和密码子 - 反密码子相互作用）无关的其他因素决定的。还提出了一种可能性，即它们之间密码子使用的这种差异是由于恒定区存在二级结构而可变区不存在。
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